Publication: Coronary Heart Disease Genetic Risk Score Predicts Cardiovascular Disease Risk in Men, Not Women.

Information

PGS Catalog Publication (PGP) ID: PGP000044
PubMed ID: 30354305
doi: 10.1161/CIRCGEN.118.002324

Publication Date: Oct. 1, 2018

Journal: Circ Genom Precis Med

Authors: Hajek C, Guo X, Yao J, Hai Y, Johnson WC, Frazier-Wood AC, Post WS, Psaty BM, Taylor KD, Rotter JI.

PGS Associated with PGP000044

PGS Developed By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000149 PGS000059 (CHD46) PSS000095 Hajek C et al. (2018) Reported Trait: Incident coronary heart disease HR (top vs. bottom quartiles of GRS): 1.92 [1.19 - 3.11]
p-value (association between risk and incidence): 0.029
NR
PPM000150 PGS000059 (CHD46) PSS000094 Hajek C et al. (2018) Reported Trait: Incident coronary heart disease HR (top vs. bottom quartiles of GRS): 0.76 [0.41 - 1.39]
p-value (association between risk and incidence): 0.31
NR

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000094 Incident CHD was defined as myocardial infarction (MI), resuscitated cardiac arrest, definite or probable angina if followed by a revascularization and CHD death 1,320 individuals
[ 86 cases, 1,234 controls]
European Analysis restricted to "White participants" MESA
PSS000095 Incident CHD was defined as myocardial infarction (MI), resuscitated cardiac arrest, definite or probable angina if followed by a revascularization and CHD death 1,206 individuals
[ 144 cases, 1,062 controls]
European Analysis restricted to "White participants" MESA