Publication: An Examination of the Relationship between Lipid Levels and Associated Genetic Markers across Racial/Ethnic Populations in the Multi-Ethnic Study of Atherosclerosis.

Information

PGS Catalog Publication (PGP) ID: PGP000045
PubMed ID: 25951326
doi: 10.1371/journal.pone.0126361

Publication Date: May 7, 2015

Journal: PLoS One

Authors: Johnson L, Zhu J, Scott ER, Wineinger NE.

PGS Associated with PGP000045

PGS Developed By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000151 PGS000060 (GRS_HDL) PSS000098 Johnson L et al. (2015) Reported Trait: Serum high-density lipoprotein (HDL) levels β: 8.39 Beta (p-value): 2.76e-06 age, age^2, sex, GRS_LDL, GRS_TC, GRS_TG Association (p-value; unadjusted for covariates) < 0.001
PPM000152 PGS000060 (GRS_HDL) PSS000097 Johnson L et al. (2015) Reported Trait: Serum high-density lipoprotein (HDL) levels β: 15.58 Beta (p-value): 2.17e-07 age, age^2, sex, GRS_LDL, GRS_TC, GRS_TG Association (p-value; unadjusted for covariates) < 0.001
PPM000153 PGS000060 (GRS_HDL) PSS000096 Johnson L et al. (2015) Reported Trait: Serum high-density lipoprotein (HDL) levels β: 7.99 Beta (p-value): 0.000364 age, age^2, sex, GRS_LDL, GRS_TC, GRS_TG Association (p-value; unadjusted for covariates) < 0.001
PPM000154 PGS000060 (GRS_HDL) PSS000099 Johnson L et al. (2015) Reported Trait: Serum high-density lipoprotein (HDL) levels β: 10.97 Beta (p-value): 6.48e-10 age, age^2, sex, GRS_LDL, GRS_TC, GRS_TG Association (p-value; unadjusted for covariates) < 0.001
PPM000155 PGS000061 (GRS_LDL) PSS000098 Johnson L et al. (2015) Reported Trait: Serum low-density lipoprotein (LDL) levels β: 15.0 Beta (p-value): 0.0352 age, age^2, sex, GRS_HDL, GRS_TC, GRS_TG Association (p-value; unadjusted for covariates) < 0.001
PPM000156 PGS000061 (GRS_LDL) PSS000097 Johnson L et al. (2015) Reported Trait: Serum low-density lipoprotein (LDL) levels β: 5.58 Beta (p-value): 0.697 age, age^2, sex, GRS_HDL, GRS_TC, GRS_TG Association (p-value; unadjusted for covariates) < 0.001
PPM000157 PGS000061 (GRS_LDL) PSS000096 Johnson L et al. (2015) Reported Trait: Serum low-density lipoprotein (LDL) levels β: 30.04 Beta (p-value): 0.00282 age, age^2, sex, GRS_HDL, GRS_TC, GRS_TG Association (p-value; unadjusted for covariates) < 0.001
PPM000158 PGS000061 (GRS_LDL) PSS000099 Johnson L et al. (2015) Reported Trait: Serum low-density lipoprotein (LDL) levels β: 42.86 Beta (p-value): 1.94e-05 age, age^2, sex, GRS_HDL, GRS_TC, GRS_TG Association (p-value; unadjusted for covariates) < 0.001
PPM000159 PGS000062 (GRS_TC) PSS000098 Johnson L et al. (2015) Reported Trait: Serum total cholesterol (TC) levels β: 20.69 Beta (p-value): 0.0108 age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TG Association (p-value; unadjusted for covariates) < 0.001
PPM000160 PGS000062 (GRS_TC) PSS000097 Johnson L et al. (2015) Reported Trait: Serum total cholesterol (TC) levels β: 8.57 Beta (p-value): 0.583 age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TG Association (p-value; unadjusted for covariates) < 0.001
PPM000161 PGS000062 (GRS_TC) PSS000096 Johnson L et al. (2015) Reported Trait: Serum total cholesterol (TC) levels β: 1.99 Beta (p-value): 0.852 age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TG Association (p-value; unadjusted for covariates) < 0.001
PPM000162 PGS000062 (GRS_TC) PSS000099 Johnson L et al. (2015) Reported Trait: Serum total cholesterol (TC) levels β: -2.62 Beta (p-value): 0.815 age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TG Association (p-value; unadjusted for covariates) < 0.001
PPM000163 PGS000063 (GRS_TG) PSS000098 Johnson L et al. (2015) Reported Trait: Serum triglyceride (TG) levels β: 0.464 Beta (p-value): 1.71e-11 age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TC Association (p-value; unadjusted for covariates) < 0.001
PPM000164 PGS000063 (GRS_TG) PSS000097 Johnson L et al. (2015) Reported Trait: Serum triglyceride (TG) levels β: 0.337 Beta (p-value): 0.0107 age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TC Association (p-value; unadjusted for covariates) < 0.001
PPM000165 PGS000063 (GRS_TG) PSS000096 Johnson L et al. (2015) Reported Trait: Serum triglyceride (TG) levels β: 0.047 Beta (p-value): 0.526 age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TC
PPM000166 PGS000063 (GRS_TG) PSS000099 Johnson L et al. (2015) Reported Trait: Serum triglyceride (TG) levels β: 0.5 Beta (p-value): 1.09e-10 age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TC Association (p-value; unadjusted for covariates) < 0.001

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000096 Lipid levels are represented in mg/dL, individuals on any lipid-lowering medication (n = 1,018) were omitted from all analyses. 1,355 individuals
46.20 % Male samples
African American or Afro-Caribbean MESA MESA Classic Cohort
PSS000097 Lipid levels are represented in mg/dL, individuals on any lipid-lowering medication (n = 1,018) were omitted from all analyses. 666 individuals
50.15 % Male samples
East Asian MESA MESA Classic Cohort
PSS000098 Lipid levels are represented in mg/dL, individuals on any lipid-lowering medication (n = 1,018) were omitted from all analyses. 2,063 individuals
46.78 % Male samples
European MESA MESA Classic Cohort
PSS000099 Lipid levels are represented in mg/dL, individuals on any lipid-lowering medication (n = 1,018) were omitted from all analyses. 1,256 individuals
48.89 % Male samples
Hispanic or Latin American MESA MESA Classic Cohort