PGS Publication: PGP000048

Publication Information (EuropePMC)
Title Evaluation of polygenic risk scores for ovarian cancer risk prediction in a prospective cohort study.
PubMed ID 29730597(Europe PMC)
doi 10.1136/jmedgenet-2018-105313
Publication Date May 5, 2018
Journal J Med Genet
Author(s) Yang X, Leslie G, Gentry-Maharaj A, Ryan A, Intermaggio M, Lee A, Kalsi JK, Tyrer J, Gaba F, Manchanda R, Pharoah PDP, Gayther SA, Ramus SJ, Jacobs I, Menon U, Antoniou AC.
Released in PGS: Feb. 12, 2020

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000068 PRS_EOC PGP000048 Yang X et al. J Med Genet (2018) Epithelial ovarian cancer ovarian carcinoma 15 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000068/ScoringFiles/PGS000068.txt.gz
PGS000069 PRS_sEOC PGP000048 Yang X et al. J Med Genet (2018) Serous epithelial ovarian cancer ovarian serous carcinoma 15 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000069/ScoringFiles/PGS000069.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000188 PGS000068 (PRS_EOC) PSS000108 PGP000048
Yang X et al. (2018)
Reported Trait: all invasive epithelial ovarian cancer OR: 1.32[1.21, 1.45] C-index: 0.58[0.55, 0.6]
PPM000189 PGS000069 (PRS_sEOC) PSS000108 PGP000048
Yang X et al. (2018)
Reported Trait: serous epithelial ovarian cancer OR: 1.43[1.29, 1.58] C-index: 0.6[0.57, 0.63]

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000108 Adjudicated endpoint determined from medical notes by an outcome review committee Mean = 11.1 years
Iqr = [10.0, 12.0] years
[
  • 750 cases
  • , 1,428 controls
]
,
0.0 % Male samples
Mean = 63.0 years
Range = [50.0, 74.0] years
European UKCTOCS
PSS000108 Adjudicated endpoint determined from medical notes by an outcome review committee Mean = 11.1 years
Iqr = [10.0, 12.0] years
[
  • 489 cases
  • , 1,428 controls
]
,
0.0 % Male samples
Mean = 63.0 years
Range = [50.0, 74.0] years
European UKCTOCS