Publication: Evaluation of polygenic risk scores for ovarian cancer risk prediction in a prospective cohort study.

Information

PGS Catalog Publication (PGP) ID: PGP000048
PubMed ID: 29730597
doi: 10.1136/jmedgenet-2018-105313

Publication Date: May 5, 2018

Journal: J Med Genet

Authors: Yang X, Leslie G, Gentry-Maharaj A, Ryan A, Intermaggio M, Lee A, Kalsi JK, Tyrer J, Gaba F, Manchanda R, Pharoah PDP, Gayther SA, Ramus SJ, Jacobs I, Menon U, Antoniou AC.

PGS Associated with PGP000048

PGS Developed By This Study

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
PGS Performance Metric (PPM) ID Evaluated Score PGS Catalog Sample Set (PSS) ID Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in PGS Model PGS Performance: Other Relevant Information
PPM000188 PGS000068 (PRS_EOC) PSS000108 Yang X et al. (2018) Reported Trait: all invasive epithelial ovarian cancer OR: 1.32 [1.21 - 1.45] C-index: 0.58 [0.55 - 0.6]
PPM000189 PGS000069 (PRS_sEOC) PSS000108 Yang X et al. (2018) Reported Trait: serous epithelial ovarian cancer OR: 1.43 [1.29 - 1.58] C-index: 0.6 [0.57 - 0.63]

Evaluated Samples

PGS Catalog Sample Set (PSS) ID Detailed Phenotype Description (e.g. ICD/SNOMED codes used to identify cases) Sample Numbers Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000108 Adjudicated endpoint determined from medical notes by an outcome review committee 2,178 individuals
[ 750 cases, 1,428 controls]
0.00 % Male samples
European UKCTOCS
PSS000108 Adjudicated endpoint determined from medical notes by an outcome review committee 1,917 individuals
[ 489 cases, 1,428 controls]
0.00 % Male samples
European UKCTOCS