PGS Publication: PGP000064

Publication Information (EuropePMC)
Title Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis.
PubMed ID 28898252(Europe PMC)
doi 10.1371/journal.pmed.1002383
Publication Date Sept. 12, 2017
Journal PLoS Med
Author(s) Wheeler E, Leong A, Liu CT, Hivert MF, Strawbridge RJ, Podmore C, Li M, Yao J, Sim X, Hong J, Chu AY, Zhang W, Wang X, Chen P, Maruthur NM, Porneala BC, Sharp SJ, Jia Y, Kabagambe EK, Chang LC, Chen WM, Elks CE, Evans DS, Fan Q, Giulianini F, Go MJ, Hottenga JJ, Hu Y, Jackson AU, Kanoni S, Kim YJ, Kleber ME, Ladenvall C, Lecoeur C, Lim SH, Lu Y, Mahajan A, Marzi C, Nalls MA, Navarro P, Nolte IM, Rose LM, Rybin DV, Sanna S, Shi Y, Stram DO, Takeuchi F, Tan SP, van der Most PJ, Van Vliet-Ostaptchouk JV, Wong A, Yengo L, Zhao W, Goel A, Martinez Larrad MT, Radke D, Salo P, Tanaka T, van Iperen EPA, Abecasis G, Afaq S, Alizadeh BZ, Bertoni AG, Bonnefond A, Böttcher Y, Bottinger EP, Campbell H, Carlson OD, Chen CH, Cho YS, Garvey WT, Gieger C, Goodarzi MO, Grallert H, Hamsten A, Hartman CA, Herder C, Hsiung CA, Huang J, Igase M, Isono M, Katsuya T, Khor CC, Kiess W, Kohara K, Kovacs P, Lee J, Lee WJ, Lehne B, Li H, Liu J, Lobbens S, Luan J, Lyssenko V, Meitinger T, Miki T, Miljkovic I, Moon S, Mulas A, Müller G, Müller-Nurasyid M, Nagaraja R, Nauck M, Pankow JS, Polasek O, Prokopenko I, Ramos PS, Rasmussen-Torvik L, Rathmann W, Rich SS, Robertson NR, Roden M, Roussel R, Rudan I, Scott RA, Scott WR, Sennblad B, Siscovick DS, Strauch K, Sun L, Swertz M, Tajuddin SM, Taylor KD, Teo YY, Tham YC, Tönjes A, Wareham NJ, Willemsen G, Wilsgaard T, Hingorani AD, EPIC-CVD Consortium, EPIC-InterAct Consortium, Lifelines Cohort Study, Egan J, Ferrucci L, Hovingh GK, Jula A, Kivimaki M, Kumari M, Njølstad I, Palmer CNA, Serrano Ríos M, Stumvoll M, Watkins H, Aung T, Blüher M, Boehnke M, Boomsma DI, Bornstein SR, Chambers JC, Chasman DI, Chen YI, Chen YT, Cheng CY, Cucca F, de Geus EJC, Deloukas P, Evans MK, Fornage M, Friedlander Y, Froguel P, Groop L, Gross MD, Harris TB, Hayward C, Heng CK, Ingelsson E, Kato N, Kim BJ, Koh WP, Kooner JS, Körner A, Kuh D, Kuusisto J, Laakso M, Lin X, Liu Y, Loos RJF, Magnusson PKE, März W, McCarthy MI, Oldehinkel AJ, Ong KK, Pedersen NL, Pereira MA, Peters A, Ridker PM, Sabanayagam C, Sale M, Saleheen D, Saltevo J, Schwarz PE, Sheu WHH, Snieder H, Spector TD, Tabara Y, Tuomilehto J, van Dam RM, Wilson JG, Wilson JF, Wolffenbuttel BHR, Wong TY, Wu JY, Yuan JM, Zonderman AB, Soranzo N, Guo X, Roberts DJ, Florez JC, Sladek R, Dupuis J, Morris AP, Tai ES, Selvin E, Rotter JI, Langenberg C, Barroso I, Meigs JB.
Released in PGS: March 27, 2020

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000132 GS-G-EAS PGP000064
Wheeler E et al. PLoS Med (2017)
Hemoglobin A1c HbA1c measurement 19 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000132/ScoringFiles/PGS000132.txt.gz
PGS000127 GS-E-EUR PGP000064
Wheeler E et al. PLoS Med (2017)
Hemoglobin A1c HbA1c measurement 21 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000127/ScoringFiles/PGS000127.txt.gz
PGS000128 GS-E-AFR PGP000064
Wheeler E et al. PLoS Med (2017)
Hemoglobin A1c HbA1c measurement 22 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000128/ScoringFiles/PGS000128.txt.gz
PGS000129 GS-E-EAS PGP000064
Wheeler E et al. PLoS Med (2017)
Hemoglobin A1c HbA1c measurement 17 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000129/ScoringFiles/PGS000129.txt.gz
PGS000130 GS-G-EUR PGP000064
Wheeler E et al. PLoS Med (2017)
Hemoglobin A1c HbA1c measurement 19 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000130/ScoringFiles/PGS000130.txt.gz
PGS000131 GS-G-AFR PGP000064
Wheeler E et al. PLoS Med (2017)
Hemoglobin A1c HbA1c measurement 19 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000131/ScoringFiles/PGS000131.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000412 PGS000132 (GS-G-EAS) PSS000235 PGP000064
Wheeler E et al. (2017)
Reported Trait: Incident type 2 diabetes OR: 1.05[1.02, 1.07] age, sex
PPM000407 PGS000127 (GS-E-EUR) PSS000236 PGP000064
Wheeler E et al. (2017)
Reported Trait: Incident type 2 diabetes OR: 1.0[0.99, 1.01] age, sex
PPM000408 PGS000128 (GS-E-AFR) PSS000234 PGP000064
Wheeler E et al. (2017)
Reported Trait: Incident type 2 diabetes OR: 0.98[0.96, 1.0] age, sex
PPM000409 PGS000129 (GS-E-EAS) PSS000235 PGP000064
Wheeler E et al. (2017)
Reported Trait: Incident type 2 diabetes OR: 1.02[0.99, 1.05] age, sex
PPM000410 PGS000130 (GS-G-EUR) PSS000236 PGP000064
Wheeler E et al. (2017)
Reported Trait: Incident type 2 diabetes OR: 1.05[1.04, 1.06] age, sex
PPM000411 PGS000131 (GS-G-AFR) PSS000234 PGP000064
Wheeler E et al. (2017)
Reported Trait: Incident type 2 diabetes OR: 1.0[0.95, 1.05] age, sex

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000234 Incident type 2 diabtes defined as fasting glucose >= 7 mmol/L, 2 hour glucose >= 11.1 mmol/L, antidiabetic medication use, or a physician diagnosis of type 2 diabetes Range = [10.0, 15.0] years
[
  • 262 cases
  • , 1,644 controls
]
,
0.38 % Male samples
Mean = 57.4 years
Sd = 7.43 years
African unspecified ARIC, MESA Partial overlap with discovery GWAS
PSS000235 Incident type 2 diabtes defined as fasting glucose >= 7 mmol/L, 2 hour glucose >= 11.1 mmol/L, antidiabetic medication use, or a physician diagnosis of type 2 diabetes Range = [10.0, 15.0] years
[
  • 2,391 cases
  • , 2,682 controls
]
,
0.47 % Male samples
Mean = 55.6 years
Sd = 7.37 years
East Asian MESA, SCHS Partial overlap with discovery GWAS
PSS000236 Incident type 2 diabtes defined as fasting glucose >= 7 mmol/L, 2 hour glucose >= 11.1 mmol/L, antidiabetic medication use, or a physician diagnosis of type 2 diabetes Range = [10.0, 15.0] years
[
  • 13,145 cases
  • , 24,212 controls
]
,
0.43 % Male samples
Mean = 54.63 years
Sd = 8.27 years
European ARIC, FHS, InterAct, MESA Partial overlap with discovery GWAS