PGS Publication: PGP000070

Publication Information (EuropePMC)
Title Risk Model for Colorectal Cancer in Spanish Population Using Environmental and Genetic Factors: Results from the MCC-Spain study.
PubMed ID 28233817(Europe PMC)
doi 10.1038/srep43263
Publication Date Feb. 24, 2017
Journal Sci Rep
Author(s) Ibáñez-Sanz G, Ibáñez-Sanz G, Díez-Villanueva A, Alonso MH, Rodríguez-Moranta F, Pérez-Gómez B, Bustamante M, Martin V, Llorca J, Amiano P, Ardanaz E, Tardón A, Jiménez-Moleón JJ, Peiró R, Alguacil J, Navarro C, Guinó E, Binefa G, Fernández-Navarro P, Espinosa A, Dávila-Batista V, Molina AJ, Palazuelos C, Castaño-Vinyals G, Aragonés N, Kogevinas M, Pollán M, Moreno V.
Released in PGS: April 29, 2020

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000147 CRC21 PGP000070
Ibáñez-Sanz G et al. Sci Rep (2017)
Colorectal cancer colorectal cancer 21 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000147/ScoringFiles/PGS000147.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000446 PGS000147 (CRC21) PSS000259 PGP000070
Ibáñez-Sanz G et al. (2017)
Reported Trait: Colon cancer Odds Ratio (OR; per allele): 1.06[1.03, 1.09] environmental risk factors ( alcohol consumption, obesity, physical activity, red meat and vegetable consumption, nonsteroidal anti-inflammatory drug use), family history
PPM000447 PGS000147 (CRC21) PSS000259 PGP000070
Ibáñez-Sanz G et al. (2017)
Reported Trait: Rectal cancer Odds Ratio (OR; per allele): 1.1[1.06, 1.15] environmental risk factors ( alcohol consumption, obesity, physical activity, red meat and vegetable consumption, nonsteroidal anti-inflammatory drug use), family history
PPM000448 PGS000147 (CRC21) PSS000259 PGP000070
Ibáñez-Sanz G et al. (2017)
Reported Trait: Colorectal cancer AUROC: 0.63[0.6, 0.66] Odds Ratio (OR; per allele): 1.07[1.04, 1.1] environmental risk factors ( alcohol consumption, obesity, physical activity, red meat and vegetable consumption, nonsteroidal anti-inflammatory drug use), family history
PPM000449 PGS000147 (CRC21) PSS000259 PGP000070
Ibáñez-Sanz G et al. (2017)
Reported Trait: Colorectal cancer AUROC: 0.56[0.54, 0.58]

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000259
[
  • 1,336 cases
  • , 2,744 controls
]
,
57.21 % Male samples
Range = [25.0, 90.0] years European
(Spanish)
MCC-Spain