| Publication Information (EuropePMC) | |
| Title | Genetic Risk, Adherence to a Healthy Lifestyle, and Coronary Disease. |
| PubMed ID | 27959714(Europe PMC) |
| doi | 10.1056/NEJMoa1605086 |
| Publication Date | Nov. 13, 2016 |
| Journal | N Engl J Med |
| Author(s) | Khera AV, Emdin CA, Drake I, Natarajan P, Bick AG, Cook NR, Chasman DI, Baber U, Mehran R, Rader DJ, Fuster V, Boerwinkle E, Melander O, Orho-Melander M, Ridker PM, Kathiresan S. |
| Polygenic Score (PGS) ID | PGS Name | PGS Publication (PGP) ID | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | PGS Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000011 | GRS50 | PGP000004 Tada H et al. Eur Heart J (2015) |
Coronary artery disease | coronary artery disease | 50 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000011/ScoringFiles/PGS000011.txt.gz |
Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
|
PGS Performance Metric ID (PPM ID) |
Evaluated Score |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM000494 | PGS000011 (GRS50) | PSS000283 | PGP000076 Khera AV et al. (2016) Ext. |
Reported Trait: Incident coronary artery disease | — | — | Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.75[1.46, 2.1] | age, sex, self reported education level, 5 genetic principal components | — |
| PPM000495 | PGS000011 (GRS50) | PSS000286 | PGP000076 Khera AV et al. (2016) Ext. |
Reported Trait: Incident coronary artery disease | — | — | Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.94[1.58, 2.39] | age, self reported education level, treatment (vitamin E vs aspirin), 5 genetic principal components | — |
| PPM000496 | PGS000011 (GRS50) | PSS000285 | PGP000076 Khera AV et al. (2016) Ext. |
Reported Trait: Incident coronary artery disease | — | — | Hazard Ratio (HR; top 20% of score vs bottom 20%): 1.98[1.76, 2.23] | age, sex, self reported education level | — |
| PPM000497 | PGS000011 (GRS50) | PSS000284 | PGP000076 Khera AV et al. (2016) Ext. |
Reported Trait: Coronary artery calcification | — | — | Agatston score (mean, top 20% of GRS): 46.0[9.0, 54.0] Agatston score (mean, btttom 25% of GRS): 21.0[18.0, 25.0] |
— | — |
|
PGS Sample Set ID (PSS ID) |
Detailed Phenotype Description | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000286 | Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary causes. | Mean = 20.5 years | [ ,
0.0 % Male samples |
Mean = 54.2 years Sd = 7.1 years |
European | — | WGHS | — |
| PSS000283 | Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary causes. | Mean = 18.8 years | [ ,
45.0 % Male samples |
Mean = 54.0 years Sd = 5.7 years |
European | — | ARIC | — |
| PSS000284 | Cross-sectional analysis of baseline scores for coronary artery calcification (Agatston score) | — | 4,260 individuals, 44.0 % Male samples |
Mean = 69.1 years Sd = 6.0 years |
European | — | BioImage | — |
| PSS000285 | Composite endpoint of either: myocardial infarction, coronary revascularization, death from coronary causes. | Mean = 19.4 years | [ ,
38.0 % Male samples |
Mean = 58.0 years Sd = 7.7 years |
European | — | MDC-CC | — |