PGS Preprint: PGP000077

Publication Information (EuropePMC)
Title Family history and polygenic risk of cardiovascular disease: independent factors associated with secondary cardiovascular manifestations in patients undergoing carotid endarterectomy
doi 10.1101/19006718
Publication Date Sept. 18, 2019
Journal medRxiv Preprint
Author(s) Timmerman N, de Kleijn DP, de Borst GJ, den Ruijter HM, Asselbergs FW, Pasterkamp G, Haitjema S, van der Laan SW.
Released in PGS: April 29, 2020

Associated Polygenic Score(s)

External PGS Evaluated By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000018 metaGRS_CAD PGP000007
Inouye M et al. J Am Coll Cardiol (2018)
Coronary artery disease coronary artery disease 1,745,180 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000018/ScoringFiles/PGS000018.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000518 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Plaque vulnerability score β: 0.07[0.003, 0.137] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000517 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Microvessels β: 0.037[-0.006, 0.08] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000516 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Number of smoooth muscle cells β: -0.004[-0.038, 0.031] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000515 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Number of macrophages β: 0.01[-0.015, 0.036] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000514 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy macrophages OR: 1.103[0.983, 1.237] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000513 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy smooth muscle cells OR: 1.004[0.88, 1.145] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000512 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Presence of IPH OR: 1.126[0.999, 1.27] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000511 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Presence of lipid core >10% OR: 1.171[1.026, 1.337] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000510 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy collagen OR: 1.064[0.919, 1.231] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000509 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy calficiations OR: 0.94[0.826, 1.07] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000508 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Plaque vulnerability score OR: 0.198[0.003, 0.364] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000507 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Microvessels Beta (top 20% vs. rest): 0.072[-0.037, 0.182] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000506 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Number of smoooth muscle cells Beta (top 20% vs. rest): -0.056[-0.143, 0.031] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000505 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Number of macrophages Beta (top 20% vs. rest): 0.55[-0.012, 0.121] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000504 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy macrophages Odds Ratio (OR; top 20% vs. rest): 1.49[1.118, 1.986] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000503 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy smooth muscle cells Odds Ratio (OR; top 20% vs. rest): 0.908[0.652, 1.265] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000502 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Presence of IPH Odds Ratio (OR; top 20% vs. rest): 1.112[0.821, 1.506] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000501 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Presence of lipid core >10% Odds Ratio (OR; top 20% vs. rest): 1.591[1.105, 2.291] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000500 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy collagen Odds Ratio (OR; top 20% vs. rest): 1.091[0.755, 1.577] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000499 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Moderate/heavy calficiations Odds Ratio (OR; top 20% vs. rest): 1.001[0.754, 1.33] Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs
PPM000498 PGS000018 (metaGRS_CAD) PSS000287 PGP000077
Timmerman N et al. (2019)
Ext. Pre
Reported Trait: Secondary cardiovascular events HR: 1.15[1.02, 1.29] Age, sex, diabetes, BMI, smoking, hypercholesterolemia, array, 4 genetics PCs

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000287 (i) Secondary cardiovascular events (sCVE; incl myocardial infarction, stroke, ruptured abdominal aortic aneurysm, fatal cardiac failure, percuteneous of bypass surgery, leg amputation due to cardiovascular causes, cardiovascular death), (ii) atherosclerotic carotid plaque characteristics Mean = 3.0 years 1,319 individuals,
69.3 % Male samples
Mean = 68.8 years
Sd = 9.3 years
European
(Dutch)
AEGS1