| Publication Information (EuropePMC) | |
| Title | Polymorphisms associated with cholesterol and risk of cardiovascular events. |
| PubMed ID | 18354102(Europe PMC) |
| doi | 10.1056/nejmoa0706728 |
| Publication Date | March 1, 2008 |
| Journal | N Engl J Med |
| Author(s) | Kathiresan S, Melander O, Anevski D, Guiducci C, Burtt NP, Roos C, Hirschhorn JN, Berglund G, Hedblad B, Groop L, Altshuler DM, Newton-Cheh C, Orho-Melander M. |
| Polygenic Score (PGS) ID | PGS Name | PGS Publication (PGP) ID | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | PGS Scoring File (FTP Link) |
|---|---|---|---|---|---|---|
| PGS000192 | GS9 | PGP000079 Kathiresan S et al. N Engl J Med (2008) |
Cholesterol | low density lipoprotein cholesterol measurement high density lipoprotein cholesterol measurement |
9 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000192/ScoringFiles/PGS000192.txt.gz |
Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
|
PGS Performance Metric ID (PPM ID) |
Evaluated Score |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|---|
| PPM000561 | PGS000192 (GS9) | PSS000292 | PGP000079 Kathiresan S et al. (2008) |
Reported Trait: Low-density lipoprotein (LDL) levels | — | — | Association p-value: 3e-24 | — | — |
| PPM000562 | PGS000192 (GS9) | PSS000292 | PGP000079 Kathiresan S et al. (2008) |
Reported Trait: High-density lipoprotein (HDL) levels | — | — | Association p-value: 2e-18 | — | — |
| PPM000563 | PGS000192 (GS9) | PSS000292 | PGP000079 Kathiresan S et al. (2008) |
Reported Trait: Incident cardiovascular event | — | AUROC: 0.8 | Hazard Ratio (HR; per allele): 1.15[1.07, 1.24] | age, sex, family history of MI, LDL cholesterol, HDL cholesterol, triglycerides, blood pressure, body mass index, diabetes status, smoking status, CRP, lipid lowering medication | — |
|
PGS Sample Set ID (PSS ID) |
Detailed Phenotype Description | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000292 | Composite end point of cardiovascular events was defined as myocardial infarction, ischemic stroke, and death from coronary heart disease. Death from coronary heart disease was defined on the basis of codes 412 and 414 (ICD-9) or I22–I23 and I25 (ICD-10) in the Swedish Cause of Death Register. Myocardial infarction was defined on the basis of codes 410 and I21 in the International Classification of Diseases, 9th Revision and 10th Revision (ICD-9 and ICD-10), respectively. Ischemic stroke was defined on the basis of codes 434 or 436 (ICD-9) and I63 or I64 (ICD-10). | Median = 10.6 years | [
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— | European | — | MDC | — |