PGS Publication: PGP000082

Publication Information (EuropePMC)
Title Genetic risk prediction and a 2-stage risk screening strategy for coronary heart disease.
PubMed ID 23599444(Europe PMC)
doi 10.1161/atvbaha.112.301120
Publication Date April 18, 2013
Journal Arterioscler Thromb Vasc Biol
Author(s) Tikkanen E, Havulinna AS, Palotie A, Salomaa V, Ripatti S.
Released in PGS: June 3, 2020

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000200 GRS28 PGP000082
Tikkanen E et al. Arterioscler Thromb Vasc Biol (2013)
Coronary heart disease coronary heart disease 28 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000200/ScoringFiles/PGS000200.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000584 PGS000200 (GRS28) PSS000329 PGP000082
Tikkanen E et al. (2013)
Reported Trait: Incident coronary heart disease HR: 1.27[1.2, 1.35] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression
PPM000585 PGS000200 (GRS28) PSS000328 PGP000082
Tikkanen E et al. (2013)
Reported Trait: Incident acute coronary syndrome HR: 1.27[1.18, 1.37] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression
PPM000586 PGS000200 (GRS28) PSS000330 PGP000082
Tikkanen E et al. (2013)
Reported Trait: Incident cardiovascular disease C-index: 0.84 ΔC-index (over covariate only model): 0.003[0.002, 0.004] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression
PPM000587 PGS000200 (GRS28) PSS000329 PGP000082
Tikkanen E et al. (2013)
Reported Trait: Incident coronary heart disease C-index: 0.856 ΔC-index (over covariate only model): 0.005[0.004, 0.006] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression
PPM000588 PGS000200 (GRS28) PSS000328 PGP000082
Tikkanen E et al. (2013)
Reported Trait: Incident acute coronary syndrome C-index: 0.859 ΔC-index (over covariate only model): 0.004[0.003, 0.005] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus, family history Age as timescale Cox regression
PPM000583 PGS000200 (GRS28) PSS000330 PGP000082
Tikkanen E et al. (2013)
Reported Trait: Incident cardiovascular disease HR: 1.18[1.12, 1.24] sex, total cholesterol, high-density lipoprotein–cholesterol, body mass index, systolic blood pressure, antihypertensive treatment, smoking, type 2 diabetes mellitus Age as timescale Cox regression

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 19.0 years
[
  • 235 cases
  • , 4,869 controls
]
,
44.8 % Male samples
Mean = 43.9 years
Sd = 11.3 years
European
(Finnish)
FINRISK FINRISK 1992
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 14.0 years
[
  • 229 cases
  • , 6,338 controls
]
,
45.8 % Male samples
Mean = 46.8 years
Sd = 12.9 years
European
(Finnish)
FINRISK97 FINRISK 1997
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 9.0 years
[
  • 148 cases
  • , 7,182 controls
]
,
45.0 % Male samples
Mean = 47.5 years
Sd = 13.0 years
European
(Finnish)
FINRISK FINRISK 2002
PSS000328 ACS was defined as MI, unstable angina or death due to CHD. Mean = 8.0 years
[
  • 119 cases
  • , 5,004 controls
]
,
46.3 % Male samples
Mean = 50.0 years
Sd = 11.7 years
European
(Finnish)
Health 2000
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 19.0 years
[
  • 343 cases
  • , 4,761 controls
]
,
44.8 % Male samples
Mean = 43.9 years
Sd = 11.3 years
European
(Finnish)
FINRISK FINRISK 1992
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 14.0 years
[
  • 344 cases
  • , 6,223 controls
]
,
45.8 % Male samples
Mean = 46.8 years
Sd = 12.9 years
European
(Finnish)
FINRISK97 FINRISK 1997
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 9.0 years
[
  • 209 cases
  • , 7,121 controls
]
,
45.0 % Male samples
Mean = 47.5 years
Sd = 13.0 years
European
(Finnish)
FINRISK FINRISK 2002
PSS000329 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. Mean = 8.0 years
[
  • 197 cases
  • , 4,926 controls
]
,
46.3 % Male samples
Mean = 50.0 years
Sd = 11.7 years
European
(Finnish)
Health 2000
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 19.0 years
[
  • 501 cases
  • , 4,603 controls
]
,
44.8 % Male samples
Mean = 43.9 years
Sd = 11.3 years
European
(Finnish)
FINRISK FINRISK 1992
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 14.0 years
[
  • 499 cases
  • , 6,068 controls
]
,
45.8 % Male samples
Mean = 46.8 years
Sd = 12.9 years
European
(Finnish)
FINRISK97 FINRISK 1997
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 9.0 years
[
  • 291 cases
  • , 7,039 controls
]
,
45.0 % Male samples
Mean = 47.5 years
Sd = 13.0 years
European
(Finnish)
FINRISK FINRISK 2002
PSS000330 CHD was defined as myocardial infarction, unstable angina pectoris, coronary revascularization (coronary artery bypass graft or percutaneous transluminal coronary angioplasty), or death due to CHD. CVD included CHD and ischemic stroke events. Mean = 8.0 years
[
  • 261 cases
  • , 4,862 controls
]
,
46.3 % Male samples
Mean = 50.0 years
Sd = 11.7 years
European
(Finnish)
Health 2000