PGS Publication: PGP000087

Publication Information (EuropePMC)
Title A cumulative genetic risk score predicts progression in Parkinson's disease.
PubMed ID 26853697(Europe PMC)
doi 10.1002/mds.26505
Publication Date Feb. 8, 2016
Journal Mov Disord
Author(s) Pihlstrøm L, Morset KR, Grimstad E, Vitelli V, Toft M.
Released in PGS: July 1, 2020

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000211 PD19 PGP000087
Pihlstrøm L et al. Mov Disord (2016)
Parkinson's disease Parkinson's disease 19 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000211/ScoringFiles/PGS000211.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000648 PGS000211 (PD19) PSS000358 PGP000087
Pihlstrøm L et al. (2016)
Reported Trait: Motor decline (time to Hoehn & Yahr ≥ 3) HR: 1.29[1.06, 1.56] sex, age at diagnosis

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000358 UPDRS motor severity was estimated as a mean value acrosseach patient’s recordings, relative to the rest of the data Mean = 5946.0 days
Sd = 2299.0 days
Range = [1574.0, 13992.0] days
[
  • 336 cases
  • , 0 controls
]
,
66.0 % Male samples
Range = [35.0, 85.0] years European Testing dataset genotyped as part of a larger study of a total of 1380 patients with idiopathic PD and 1295 control subjects by 5 collaborating groups in Norway and Sweden. (https://www.sciencedirect.com/science/article/abs/pii/S0197458012005301?showall%3Dtrue%26via%3Dihub)