PGS Publication: PGP000092

Publication Information (EuropePMC)
Title Genetic Risk Scores for Complex Disease Traits in Youth.
PubMed ID 32527150(Europe PMC)
doi 10.1161/circgen.119.002775
Publication Date June 11, 2020
Journal Circ Genom Precis Med
Author(s) Xie T, Wang B, Nolte IM, van der Most PJ, Oldehinkel AJ, Hartman CA, Snieder H.
Released in PGS: Aug. 19, 2020

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000297 GRS3290_Height PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Height body height 3,290 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000297/ScoringFiles/PGS000297.txt.gz
PGS000308 GRS12_FIadjBMI PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Fasting insulin (body mass index adjusted) BMI-adjusted fasting blood insulin measurement 12 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000308/ScoringFiles/PGS000308.txt.gz
PGS000300 GRS80_HR PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Heart rate resting heart rate 80 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000300/ScoringFiles/PGS000300.txt.gz
PGS000299 GRS462_WHRadjBMI PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Waist-to-hip ratio (body mass index adjusted) BMI-adjusted waist-hip ratio 462 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000299/ScoringFiles/PGS000299.txt.gz
PGS000298 GRS941_BMI PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Body mass index body mass index 941 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000298/ScoringFiles/PGS000298.txt.gz
PGS000307 GRS12_FI PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Fasting insulin fasting blood insulin measurement 12 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000307/ScoringFiles/PGS000307.txt.gz
PGS000306 GRS19_FGadjBMI PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Fasting glucose (body mass index adjusted) BMI-adjusted fasting blood glucose measurement 19 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000306/ScoringFiles/PGS000306.txt.gz
PGS000305 GRS31_FG PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Fasting glucose fasting blood glucose measurement 31 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000305/ScoringFiles/PGS000305.txt.gz
PGS000304 GRS43_HbA1c PGP000092
Xie T et al. Circ Genom Precis Med (2020)
HbA1c HbA1c measurement 43 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000304/ScoringFiles/PGS000304.txt.gz
PGS000303 GRS253_eGFR PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Estimated glomerular filtration rate glomerular filtration rate 253 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000303/ScoringFiles/PGS000303.txt.gz
PGS000302 GRS962_DBP PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Diastolic blood pressure diastolic blood pressure 962 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000302/ScoringFiles/PGS000302.txt.gz
PGS000301 GRS970_SBP PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Systolic blood pressure systolic blood pressure 970 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000301/ScoringFiles/PGS000301.txt.gz
PGS000315 GRS7_lgE PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Immunoglobulin E (IgE) serum IgE measurement 7 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000315/ScoringFiles/PGS000315.txt.gz
PGS000314 GRS77_CRP PGP000092
Xie T et al. Circ Genom Precis Med (2020)
C-reactive protein C-reactive protein measurement 77 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000314/ScoringFiles/PGS000314.txt.gz
PGS000313 GRS49_Lp(a) PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Lipoprotein(a) lipoprotein A measurement 49 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000313/ScoringFiles/PGS000313.txt.gz
PGS000312 GRS190_TG PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Triglycerides triglyceride measurement 190 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000312/ScoringFiles/PGS000312.txt.gz
PGS000311 GRS234_TC PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Total cholesterol total cholesterol measurement 234 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000311/ScoringFiles/PGS000311.txt.gz
PGS000310 GRS194_LDL PGP000092
Xie T et al. Circ Genom Precis Med (2020)
Low-density lipoprotein low density lipoprotein cholesterol measurement 194 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000310/ScoringFiles/PGS000310.txt.gz
PGS000309 GRS247_HDL PGP000092
Xie T et al. Circ Genom Precis Med (2020)
High-density lipoprotein high density lipoprotein cholesterol measurement 247 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000309/ScoringFiles/PGS000309.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000757 PGS000297 (GRS3290_Height) PSS000375 PGP000092
Xie T et al. (2020)
Reported Trait: Height (cm) : 0.1172 Sex, age
PPM000758 PGS000297 (GRS3290_Height) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Height (cm) : 0.1368 Sex, age
PPM000759 PGS000297 (GRS3290_Height) PSS000377 PGP000092
Xie T et al. (2020)
Reported Trait: Height (cm) : 0.1273 Sex, age
PPM000760 PGS000297 (GRS3290_Height) PSS000378 PGP000092
Xie T et al. (2020)
Reported Trait: Height (cm) : 0.1382 Sex, age
PPM000761 PGS000298 (GRS941_BMI) PSS000374 PGP000092
Xie T et al. (2020)
Reported Trait: Body mass index (kg/m2) : 0.0579 Sex, age
PPM000762 PGS000298 (GRS941_BMI) PSS000375 PGP000092
Xie T et al. (2020)
Reported Trait: Body mass index (kg/m2) : 0.0612 Sex, age
PPM000763 PGS000298 (GRS941_BMI) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Body mass index (kg/m2) : 0.0647 Sex, age
PPM000764 PGS000298 (GRS941_BMI) PSS000377 PGP000092
Xie T et al. (2020)
Reported Trait: Body mass index (kg/m2) : 0.0655 Sex, age
PPM000765 PGS000298 (GRS941_BMI) PSS000378 PGP000092
Xie T et al. (2020)
Reported Trait: Body mass index (kg/m2) : 0.0591 Sex, age
PPM000766 PGS000299 (GRS462_WHRadjBMI) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Waist-to-hip ratio : 0.0138 Sex, age, age^2, BMI
PPM000767 PGS000299 (GRS462_WHRadjBMI) PSS000377 PGP000092
Xie T et al. (2020)
Reported Trait: Waist-to-hip ratio : 0.0141 Sex, age, age^2, BMI
PPM000768 PGS000299 (GRS462_WHRadjBMI) PSS000378 PGP000092
Xie T et al. (2020)
Reported Trait: Waist-to-hip ratio : 0.0195 Sex, age, age^2, BMI
PPM000769 PGS000300 (GRS80_HR) PSS000374 PGP000092
Xie T et al. (2020)
Reported Trait: Heart rate (bpm) : 0.0211 Sex, age, age^2, BMI
PPM000756 PGS000297 (GRS3290_Height) PSS000374 PGP000092
Xie T et al. (2020)
Reported Trait: Height (cm) : 0.1192 Sex, age
PPM000771 PGS000301 (GRS970_SBP) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Systolic blood pressure (mmHg) : 0.0215 Sex, age, age^2, BMI
PPM000773 PGS000303 (GRS253_eGFR) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Estimated glomerular filtration rate (mL/min per 1.73 m2) : 0.0504 Sex, age
PPM000776 PGS000306 (GRS19_FGadjBMI) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Fasting glucose (mmol/l) : 0.0095 Sex, age, BMI
PPM000770 PGS000300 (GRS80_HR) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Heart rate (bpm) : 0.0146 Sex, age, age^2, BMI
PPM000772 PGS000302 (GRS962_DBP) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Diastolic blood pressure (mmHg) : 0.0448 Sex, age, age^2, BMI
PPM000774 PGS000304 (GRS43_HbA1c) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: HbA1c (%) : 0.0283 Sex, age, age^2
PPM000775 PGS000305 (GRS31_FG) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Fasting glucose (mmol/l) : 0.0367 Sex, age, age^2
PPM000778 PGS000308 (GRS12_FIadjBMI) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Fasting insulin (mU/I) : 0.0069 Sex, age, BMI
PPM000779 PGS000309 (GRS247_HDL) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: High-density lipoprotein (mmol/l) : 0.1149 Sex, age, age^2
PPM000780 PGS000310 (GRS194_LDL) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Low-density lipoprotein (mmol/l) : 0.1849 Sex, age, age^2
PPM000781 PGS000311 (GRS234_TC) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Total cholesterol (mmol/l) : 0.1295 Sex, age, age^2
PPM000782 PGS000312 (GRS190_TG) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Triglycerides (mmol/l) : 0.0656 Sex, age, age^2
PPM000783 PGS000313 (GRS49_Lp(a)) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Lipoprotein(a) (mg/l) : 0.3959 Sex, age, age^2
PPM000784 PGS000314 (GRS77_CRP) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: C-reactive protein (mg/l) : 0.0369 Sex, age
PPM000785 PGS000315 (GRS7_lgE) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Immunoglobulin E (kU/I) : 0.0206 Sex, age
PPM000786 PGS000297 (GRS3290_Height) PSS000369 PGP000092
Xie T et al. (2020)
Reported Trait: Height (cm) : 0.087 Sex, age
PPM000787 PGS000297 (GRS3290_Height) PSS000370 PGP000092
Xie T et al. (2020)
Reported Trait: Height (cm) : 0.0755 Sex, age
PPM000788 PGS000297 (GRS3290_Height) PSS000371 PGP000092
Xie T et al. (2020)
Reported Trait: Height (cm) : 0.0887 Sex, age
PPM000789 PGS000297 (GRS3290_Height) PSS000372 PGP000092
Xie T et al. (2020)
Reported Trait: Height (cm) : 0.0986 Sex, age
PPM000790 PGS000297 (GRS3290_Height) PSS000373 PGP000092
Xie T et al. (2020)
Reported Trait: Height (cm) : 0.1158 Sex, age
PPM000791 PGS000298 (GRS941_BMI) PSS000369 PGP000092
Xie T et al. (2020)
Reported Trait: Body mass index (kg/m2) : 0.0671 Sex, age
PPM000792 PGS000298 (GRS941_BMI) PSS000370 PGP000092
Xie T et al. (2020)
Reported Trait: Body mass index (kg/m2) : 0.057 Sex, age
PPM000793 PGS000298 (GRS941_BMI) PSS000371 PGP000092
Xie T et al. (2020)
Reported Trait: Body mass index (kg/m2) : 0.0886 Sex, age
PPM000794 PGS000298 (GRS941_BMI) PSS000372 PGP000092
Xie T et al. (2020)
Reported Trait: Body mass index (kg/m2) : 0.092 Sex, age
PPM000795 PGS000298 (GRS941_BMI) PSS000373 PGP000092
Xie T et al. (2020)
Reported Trait: Body mass index (kg/m2) : 0.1194 Sex, age
PPM000796 PGS000299 (GRS462_WHRadjBMI) PSS000371 PGP000092
Xie T et al. (2020)
Reported Trait: Waist-to-hip ratio : 0.01 Sex, age, age^2, BMI
PPM000797 PGS000299 (GRS462_WHRadjBMI) PSS000372 PGP000092
Xie T et al. (2020)
Reported Trait: Waist-to-hip ratio : 0.017 Sex, age, age^2, BMI
PPM000798 PGS000299 (GRS462_WHRadjBMI) PSS000373 PGP000092
Xie T et al. (2020)
Reported Trait: Waist-to-hip ratio : 0.0156 Sex, age, age^2, BMI
PPM000799 PGS000300 (GRS80_HR) PSS000369 PGP000092
Xie T et al. (2020)
Reported Trait: Heart rate (bpm) : 0.0028 Sex, age, age^2, BMI
PPM000800 PGS000300 (GRS80_HR) PSS000371 PGP000092
Xie T et al. (2020)
Reported Trait: Heart rate (bpm) : 0.0223 Sex, age, age^2, BMI
PPM000801 PGS000301 (GRS970_SBP) PSS000371 PGP000092
Xie T et al. (2020)
Reported Trait: Systolic blood pressure (mmHg) : 0.012 Sex, age, age^2, BMI
PPM000802 PGS000302 (GRS962_DBP) PSS000371 PGP000092
Xie T et al. (2020)
Reported Trait: Diastolic blood pressure (mmHg) : 0.0088 Sex, age, age^2, BMI
PPM000803 PGS000304 (GRS43_HbA1c) PSS000371 PGP000092
Xie T et al. (2020)
Reported Trait: HbA1c (%) : 0.0277 Sex, age, age^2
PPM000777 PGS000307 (GRS12_FI) PSS000376 PGP000092
Xie T et al. (2020)
Reported Trait: Fasting insulin (mU/I) : 0.0145 Sex, age

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000369 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 334 individuals,
69.2 % Male samples
Mean = 11.1 years
Sd = 0.48 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000370 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 329 individuals,
69.2 % Male samples
Mean = 12.81 years
Sd = 0.59 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000371 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 288 individuals,
69.2 % Male samples
Mean = 15.83 years
Sd = 0.6 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000372 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 265 individuals,
69.2 % Male samples
Mean = 19.2 years
Sd = 0.66 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000373 Individuals who have been referred to a child psychiatric outpatient clinic in the Northern Netherlands before the age of 11. We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 245 individuals,
69.2 % Male samples
Mean = 22.04 years
Sd = 0.69 years
European TRAILS, TRAILSCC TRAILS Clinical Cohort
PSS000374 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,318 individuals,
47.6 % Male samples
Mean = 11.1 years European TRAILS
PSS000375 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,313 individuals,
47.6 % Male samples
Mean = 13.5 years European TRAILS
PSS000376 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,354 individuals,
47.56 % Male samples
Mean = 16.22 years
Sd = 0.66 years
European TRAILS
PSS000377 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,174 individuals,
47.6 % Male samples
Mean = 19.2 years European TRAILS
PSS000378 We measured weight and height using regularly calibrated equipment (scales and stadiometer models 770 and 214, respectively; Seca, Hamburg, Germany). Body mass index (BMI; in kg/m2) was also calculated. We measured waist circumference at the midpoint between the lower costal margin and the iliac crest. The hip circumference was measured over both trochanter majores (tangible bone on the outside of the hip joint). Waist to hip ratio was also calculated. We performed all measurements in duplicate, and, if the difference between these measurements exceeded a predefined value, a third measurement was performed. All available measurements were used to calculate means. Heart rate, systolic (SBP) and diastolic (DBP) blood pressure were measured in duplicate with a Dinamap Critikon 1846SX (Critikon Inc, Tampa, FL), from which we calculated means. At the third visit, fasting blood sample of participants were drawn for the measurement of glucose (Roche Diagnostics, Basel, Switzerland), insulin (Diagnostic Systems Laboratories Inc, Webster, TX), HbA1c (high performance liquid chromatography, Variant, Bio-Rad), triglycerides, total cholesterol, HDL cholesterol (Roche Diagnostics) and LDL cholesterol (calculated according to Friedewald’s equation5), as well as alanine transaminase (Photometric determination according to the reference method of the International Federation of Clinical Chemistry (IFCC)6) and lipoprotein(a) (Nephelometric method, BN2, DadeBehring). Serum creatinine was measured by photometric determination with the Jaffé method without deproteinisation (Ecoline® MEGA, DiaSys Diagnostic Systems GmbH. Merck). eGFR for adolescents who were younger than 18 years old was calculated using the Schwartz formula.7 High‐sensitivity C‐reactive protein (hsCRP) was determined using an immunonephelometric method, BN2 (CardioPhase hsCRP, Siemens) with a lower detection limit of 0.175 mg/L. Total IgE measurements were performed using the Phadia Immunocap 100 system with fluoroenzyme immunoassay (FEIA). 1,095 individuals,
47.6 % Male samples
Mean = 22.4 years European TRAILS