PGS Publication: PGP000101

Publication Information (EuropePMC)
Title Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture.
PubMed ID 32968074(Europe PMC)
doi 10.1038/s41467-020-18534-1
Publication Date Sept. 23, 2020
Journal Nat Commun
Author(s) Zhang Q, Sidorenko J, Couvy-Duchesne B, Marioni RE, Wright MJ, Goate AM, Marcora E, Huang KL, Porter T, Laws SM, Australian Imaging Biomarkers and Lifestyle (AIBL) Study, Sachdev PS, Mather KA, Armstrong NJ, Thalamuthu A, Brodaty H, Yengo L, Yang J, Wray NR, McRae AF, Visscher PM.
Released in PGS: Oct. 16, 2020

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000334 GRSfull_22 PGP000101 Zhang Q et al. Nat Commun (2020) Late-onset Alzheimer’s disease late-onset Alzheimers disease 22 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000334/ScoringFiles/PGS000334.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID) 		Evaluated Score PGS Sample Set ID
(PSS ID) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000901 PGS000334 (GRSfull_22) PSS000449 PGP000101
Zhang Q et al. (2020) 		Reported Trait: Late-onset Alzheimer’s disease — — R²: 0.191[0.131, 0.269] — R2 = variance explained on the liability scale

Evaluated Samples

PGS Sample Set ID
(PSS ID) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000449 — —
[
  • 216 cases
  • , 631 controls
]
,
54.7 % Male samples
 Mean (Cases) = 77.6 years
Sd (Cases) = 7.6 years		 European — ABIL —
PSS000449 — —
[
  • 77 cases
  • , 588 controls
]
,
44.4 % Male samples
 Mean (Cases) = 86.8 years
Sd (Cases) = 4.6 years		 European — MAS —
PSS000449 — —
[
  • 383 cases
  • , 1,915 controls
]
,
47.0 % Male samples
 Mean (Cases) = 64.4 years
Sd (Cases) = 4.5 years		 European — UKB —