Publication Information (EuropePMC) | |
Title | Risk prediction of late-onset Alzheimer's disease implies an oligogenic architecture. |
PubMed ID | 32968074(Europe PMC) |
doi | 10.1038/s41467-020-18534-1 |
Publication Date | Sept. 23, 2020 |
Journal | Nat Commun |
Author(s) | Zhang Q, Sidorenko J, Couvy-Duchesne B, Marioni RE, Wright MJ, Goate AM, Marcora E, Huang KL, Porter T, Laws SM, Australian Imaging Biomarkers and Lifestyle (AIBL) Study, Sachdev PS, Mather KA, Armstrong NJ, Thalamuthu A, Brodaty H, Yengo L, Yang J, Wray NR, McRae AF, Visscher PM. |
Polygenic Score (PGS) ID | PGS Name | PGS Publication (PGP) ID | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | PGS Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS000334 | GRSfull_22 | PGP000101 Zhang Q et al. Nat Commun (2020) | Late-onset Alzheimer’s disease | late-onset Alzheimers disease | 22 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000334/ScoringFiles/PGS000334.txt.gz |
PGS Performance Metric ID (PPM ID) |
Evaluated Score |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM000901 | PGS000334 (GRSfull_22) | PSS000449 | PGP000101 Zhang Q et al. (2020) |
Reported Trait: Late-onset Alzheimer’s disease | — | — | R²: 0.191 [0.131, 0.269] | — | R2 = variance explained on the liability scale |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000449 | — | — | [ ,
54.7 % Male samples |
Mean (Cases) = 77.6 years Sd (Cases) = 7.6 years |
European | — | ABIL | — |
PSS000449 | — | — | [ ,
44.4 % Male samples |
Mean (Cases) = 86.8 years Sd (Cases) = 4.6 years |
European | — | MAS | — |
PSS000449 | — | — | [ ,
47.0 % Male samples |
Mean (Cases) = 64.4 years Sd (Cases) = 4.5 years |
European | — | UKB | — |