PGS Publication: PGP000105

Publication Information (EuropePMC)
Title Genetic risk and atrial fibrillation in patients with heart failure.
PubMed ID 31919934(Europe PMC)
doi 10.1002/ejhf.1735
Publication Date Jan. 9, 2020
Journal Eur J Heart Fail
Author(s) Kloosterman M, Santema BT, Roselli C, Nelson CP, Koekemoer A, Romaine SPR, Van Gelder IC, Lam CSP, Artola VA, Lang CC, Ng LL, Metra M, Anker S, Filippatos G, Dickstein K, Ponikowski P, van der Harst P, van der Meer P, van Veldhuisen DJ, Benjamin EJ, Voors AA, Samani NJ, Rienstra M.
Released in PGS Catalog: Nov. 5, 2020

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000338 GRS97_AF PGP000105 Kloosterman M et al. Eur J Heart Fail (2020) Atrial fibrillation atrial fibrillation 97 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000338/ScoringFiles/PGS000338.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000918 PGS000338 (GRS97_AF) PSS000460 PGP000105
Kloosterman M et al. (2020)
Reported Trait: Atrial fibrillation in individuals with heart failure and a preserved ejection fraction OR: 1.82[1.28, 2.59] age, sex, PCs (1-10) of ancestry
PPM000919 PGS000338 (GRS97_AF) PSS000462 PGP000105
Kloosterman M et al. (2020)
Reported Trait: Atrial fibrillation AUROC: 0.606[0.588, 0.624] PCs (1-10) of ancestry
PPM000920 PGS000338 (GRS97_AF) PSS000462 PGP000105
Kloosterman M et al. (2020)
Reported Trait: Atrial fibrillation AUROC: 0.721[0.704, 737.0] PCs (1-10) of ancestry, CHARGE-AF risk factors (age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, myocardial infarction, diabetes)
PPM000913 PGS000338 (GRS97_AF) PSS000462 PGP000105
Kloosterman M et al. (2020)
Reported Trait: Atrial fibrillation OR: 2.12[1.84, 2.45] age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry
PPM000914 PGS000338 (GRS97_AF) PSS000461 PGP000105
Kloosterman M et al. (2020)
Reported Trait: Atrial fibrillation in individuals with heart failure and a reduced ejection fraction OR: 2.08[1.72, 2.5] age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry
PPM000915 PGS000338 (GRS97_AF) PSS000460 PGP000105
Kloosterman M et al. (2020)
Reported Trait: Atrial fibrillation in individuals with heart failure and a preserved ejection fraction OR: 2.02[1.37, 2.99] age, height, weight, systolic blood pressure, diastolic blood pressure, current smoking, hypertension, diabetes, myocardial infarction, PCs (1-10) of ancestry
PPM000916 PGS000338 (GRS97_AF) PSS000462 PGP000105
Kloosterman M et al. (2020)
Reported Trait: Atrial fibrillation OR: 2.13[1.86, 2.44] age, sex, PCs (1-10) of ancestry
PPM000917 PGS000338 (GRS97_AF) PSS000461 PGP000105
Kloosterman M et al. (2020)
Reported Trait: Atrial fibrillation in individuals with heart failure and a reduced ejection fraction OR: 2.12[1.77, 2.54] age, sex, PCs (1-10) of ancestry

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000460 Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG. HFpEF defined as LVEF >/= 50%
[
  • 307 cases
  • , 223 controls
]
European BIOSTAT-CHF BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014
PSS000461 Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG.HFrEF defined as LVEF <40%
[
  • 1,125 cases
  • , 1,137 controls
]
European BIOSTAT-CHF BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014
PSS000462 Atrial fibrillation was defined as a clinical history of AF or atrial flutter (AFL) and/or AF(L) on baseline electrocardiogram. Patients were regarded as having sinus rhythm if they had no history of AF and sinus rhythm on baseline ECG.
[
  • 1,976 cases
  • , 1,783 controls
]
,
70.0 % Male samples
Mean = 72.8 years
Sd = 11.5 years
European BIOSTAT-CHF BIOSTAT-CHF study included patients from 11 European countries. Patients from Scotland were included in the vaidation cohort between October 2010 and April 2014