PGS Publication: PGP000111

Publication Information (EuropePMC)
Title Evaluation of a Genetic Risk Score for Diagnosis of Psoriatic Arthritis.
PubMed ID 32462110(Europe PMC)
doi 10.1177/2475530320910814
Publication Date March 4, 2020
Journal J Psoriasis Psoriatic Arthritis
Author(s) Smith MP, Ly K, Thibodeaux Q, Beck K, Yang E, Sanchez I, Nititham J, Bhutani T, Liao W.
Released in PGS Catalog: Nov. 20, 2020

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000343 wGRS_PsA_HLA PGP000111 Smith MP et al. J Psoriasis Psoriatic Arthritis (2020) Psoriatic arthritis psoriatic arthritis 5 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000343/ScoringFiles/PGS000343.txt.gz
PGS000342 wGRS_PsA PGP000111 Smith MP et al. J Psoriasis Psoriatic Arthritis (2020) Psoriatic arthritis psoriatic arthritis 11 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000342/ScoringFiles/PGS000342.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000972 PGS000343 (wGRS_PsA_HLA) PSS000490 PGP000111
Smith MP et al. (2020)
Reported Trait: Psoriatic arthritis AUROC: 0.569[0.513, 0.625]
PPM000971 PGS000342 (wGRS_PsA) PSS000490 PGP000111
Smith MP et al. (2020)
Reported Trait: Psoriatic arthritis AUROC: 0.562[0.506, 0.618]

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000490 Cases included physician-confirmed psoriatic arthritis (PsA). Controls inclded individuals with psoriasis with no history of joint symptoms (psoriasis only - PsO).
[
  • 140 cases
  • , 403 controls
]
Not reported