PGS Publication: PGP000120

Publication Information (EuropePMC)
Title Development of a polygenic risk score to improve screening for fracture risk: A genetic risk prediction study.
PubMed ID 32614825(Europe PMC)
doi 10.1371/journal.pmed.1003152
Publication Date July 2, 2020
Journal PLoS Med
Author(s) Forgetta V, Keller-Baruch J, Forest M, Durand A, Bhatnagar S, Kemp JP, Nethander M, Evans D, Morris JA, Kiel DP, Rivadeneira F, Johansson H, Harvey NC, Mellström D, Karlsson M, Cooper C, Evans DM, Clarke R, Kanis JA, Orwoll E, McCloskey EV, Ohlsson C, Pineau J, Leslie WD, Greenwood CMT, Richards JB.
Released in PGS Catalog: Dec. 15, 2020

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000657 gSOS PGP000120 Forgetta V et al. PLoS Med (2020) Heel quantitative ultrasound speed of sound (SOS) calcaneal bone quantitative ultrasound measurement 21,717 - Check Terms/Licenses

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
Evaluated Score PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001343 PGS000657 (gSOS) PSS000586 PGP000120
Forgetta V et al. (2020)
Reported Trait: Heel bone speed of sound : 0.2318 [0.2266, 0.2369]
PPM001344 PGS000657 (gSOS) PSS000585 PGP000120
Forgetta V et al. (2020)
Reported Trait: Screening incorporating a gSOS-based screening step Positive Predictive Value (PPV): 0.954
Reduction in individuals requiring Clinical-Risk-Factor FRAX tests (%): 37.0
Percent reduction in individuals requiring BMD FRAX Tests (%): 41.0

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000585 4,741 individuals,
47.5 % Male samples
Mean = 55.8 years
Sd = 7.6 years
European UKB
PSS000585 6,704 individuals,
49.3 % Male samples
Mean = 62.6 years
Sd = 9.9 years
European, NR CLSA
PSS000585 3,426 individuals,
0.0 % Male samples
Mean = 71.5 years
Sd = 5.3 years
European, NR SOF
PSS000585 4,657 individuals,
100.0 % Male samples
Mean = 74.0 years
Sd = 6.0 years
European MrOS-USA
PSS000585 1,880 individuals,
100.0 % Male samples
Mean = 75.4 years
Sd = 3.2 years
PSS000586 4,741 individuals,
47.5 % Male samples
Mean = 55.8 years
Sd = 7.6 years
European UKB