PGS Publication: PGP000122

Publication Information (EuropePMC)
Title Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
PubMed ID 33398198(Europe PMC)
doi 10.1038/s41588-020-00748-0
Publication Date Jan. 4, 2020
Journal Nat Genet
Author(s) Conti DV, Darst BF et al.
Released in PGS Catalog: Jan. 7, 2021

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000662 GRS.PCa.269 PGP000122 Conti DV, Darst BF et al. Nat Genet (2020) Prostate Cancer prostate carcinoma 269 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000662/ScoringFiles/PGS000662.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID) 		Evaluated Score PGS Sample Set ID
(PSS ID) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001365 PGS000662 (GRS.PCa.269) PSS000596 PGP000122
Conti DV, Darst BF et al. (2020) 		Reported Trait: Prostate Cancer — AUROC: 0.833 Odds ratio (OR, top 10% versus 40-60% GRS): 4.17
Overall Net Reclassification Index (NRI[%]): 59.4		 Age, 10 PCs —
PPM001366 PGS000662 (GRS.PCa.269) PSS000595 PGP000122
Conti DV, Darst BF et al. (2020) 		Reported Trait: Prostate Cancer — AUROC: 0.679 Odds ratio (OR, top 10% versus 40-60% GRS): 3.53 Age, 10 PCs, study —

Evaluated Samples

PGS Sample Set ID
(PSS ID) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000595 — —
[
  • 1,586 cases
  • , 1,047 controls
]
,
100.0 % Male samples
 — African unspecified — CAUG —
PSS000596 — —
[
  • 6,852 cases
  • , 193,117 controls
]
,
100.0 % Male samples
 — European — UKB —