PGS Publication: PGP000130

Publication Information (EuropePMC)
Title Prostate cancer risk prediction using a polygenic risk score.
PubMed ID 33051487(Europe PMC)
doi 10.1038/s41598-020-74172-z
Publication Date Oct. 13, 2020
Journal Sci Rep
Author(s) Sipeky C, Talala KM, Tammela TLJ, Taari K, Auvinen A, Schleutker J.
Released in PGS Catalog: Feb. 3, 2021

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000714 PRS55_PC PGP000130 Sipeky C et al. Sci Rep (2020) Prostate cancer prostate carcinoma 55 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000714/ScoringFiles/PGS000714.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001624 PGS000714
(PRS55_PC)
PSS000840 PGP000130 Sipeky C et al. (2020) Reported Trait: Prostate cancer OR: 2.13 [1.9, 2.39] AUROC: 0.618 [0.6, 0.63]
PPM001625 PGS000714
(PRS55_PC)
PSS000841 PGP000130 Sipeky C et al. (2020) Reported Trait: Prostate cancer (clinical cases) OR: 2.18 [1.93, 2.45] AUROC: 0.622 [0.61, 0.64]
PPM001626 PGS000714
(PRS55_PC)
PSS000843 PGP000130 Sipeky C et al. (2020) Reported Trait: Prostate cancer (screening trial detected) OR: 1.92 [1.56, 2.37] AUROC: 0.597 [0.57, 0.63]
PPM001627 PGS000714
(PRS55_PC)
PSS000842 PGP000130 Sipeky C et al. (2020) Reported Trait: Metastatic prostate cancer OR: 1.47 AUROC: 0.549

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000840 Cases: clinically diagnosed or screen-detected prostate cancer. Controls: free of cancer
[
  • 2,738 cases
  • , 2,400 controls
]
,
100.0 % Male samples
European
(Finnish)
FinRSPC, PHD
PSS000841 Cases: clinically diagnosed with prostate cancer. Controls: free of cancer.
[
  • 2,283 cases
  • , 2,400 controls
]
,
100.0 % Male samples
European
(Finnish)
FinRSPC, PHD
PSS000842
[
  • 191 cases
  • , 2,400 controls
]
,
100.0 % Male samples
European
(Finnish)
FinRSPC, PHD
PSS000843 Cases: screen-detected prostate cancer. Controls: free of cancer.
[
  • 455 cases
  • , 2,400 controls
]
,
100.0 % Male samples
European
(Finnish)
FinRSPC