PGS Publication: PGP000132

Publication Information (EuropePMC)
Title Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study.
PubMed ID 32376654(Europe PMC)
doi 10.1136/bmj.m1203
Publication Date May 6, 2020
Journal BMJ
Author(s) Richardson TG, Sanderson E, Elsworth B, Tilling K, Davey Smith G.
Released in PGS Catalog: Feb. 3, 2021

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000717 PGS557_albs PGP000132 Richardson TG et al. BMJ (2020) Adult life body size body mass index 557 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000717/ScoringFiles/PGS000717.txt.gz
PGS000716 PGS295_elbs PGP000132 Richardson TG et al. BMJ (2020) Early life body size comparative body size at age 10, self-reported
body mass index
295 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000716/ScoringFiles/PGS000716.txt.gz

PGS Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001633 PGS000716
(PGS295_elbs)
PSS000849 PGP000132 Richardson TG et al. (2020) Reported Trait: Childhood body mass index AUROC: 0.64
PPM001634 PGS000717
(PGS557_albs)
PSS000849 PGP000132 Richardson TG et al. (2020) Reported Trait: Childhood body mass index AUROC: 0.61
PPM001635 PGS000716
(PGS295_elbs)
PSS000847 PGP000132 Richardson TG et al. (2020) Reported Trait: Adolescent body mass index AUROC: 0.63
PPM001636 PGS000717
(PGS557_albs)
PSS000847 PGP000132 Richardson TG et al. (2020) Reported Trait: Adolescent body mass index AUROC: 0.63
PPM001637 PGS000716
(PGS295_elbs)
PSS000848 PGP000132 Richardson TG et al. (2020) Reported Trait: Adult body mass index AUROC: 0.57
PPM001638 PGS000717
(PGS557_albs)
PSS000848 PGP000132 Richardson TG et al. (2020) Reported Trait: Adult body mass index AUROC: 0.6

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000847 Measurs of BMI were dichotomised to classify individuals higher than th 85th centiles as overweight. 3,997 individuals Mean = 17.8 years European ALSPAC ALSPAC offspring
PSS000848 Measurs of BMI were dichotomised to classify individuals higher than th 85th centiles as overweight. 2,199 individuals,
0.0 % Male samples
Mean = 50.8 years European ALSPAC ALSPAC mothers
PSS000849 Measurs of BMI were dichotomised to classify individuals higher than th 85th centiles as overweight. 5,898 individuals Mean = 9.9 years European ALSPAC ALSPAC offspring