PGS Publication: PGP000138

Publication Information (EuropePMC)
Title Disease risk scores for skin cancers.
PubMed ID 33420020(Europe PMC)
doi 10.1038/s41467-020-20246-5
Publication Date Jan. 8, 2021
Journal Nat Commun
Author(s) Fontanillas P, Alipanahi B, Furlotte NA, Johnson M, Wilson CH, 23andMe Research Team, Pitts SJ, Gentleman R, Auton A.
Released in PGS Catalog: Feb. 23, 2021

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000730 PRS_BCC PGP000138
Fontanillas P et al. Nat Commun (2021)
Basal cell carcinoma basal cell carcinoma 47 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000730/ScoringFiles/PGS000730.txt.gz - Check Terms/Licenses
PGS000731 PRS_SCC PGP000138
Fontanillas P et al. Nat Commun (2021)
Squamous cell carcinoma squamous cell carcinoma 14 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000731/ScoringFiles/PGS000731.txt.gz - Check Terms/Licenses
PGS000732 PRS_Melanoma PGP000138
Fontanillas P et al. Nat Commun (2021)
Melanoma melanoma 18 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000732/ScoringFiles/PGS000732.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001670 PGS000730
(PRS_BCC)
PSS000871 PGP000138
Fontanillas P et al. Nat Commun (2021)
Reported Trait: Basal cell carcinoma OR: 1.57 [1.55, 1.6] AUROC: 0.624
PPM001671 PGS000731
(PRS_SCC)
PSS000873 PGP000138
Fontanillas P et al. Nat Commun (2021)
Reported Trait: Squamous cell carcinoma OR: 1.44 [1.41, 1.48] AUROC: 0.605
PPM001672 PGS000732
(PRS_Melanoma)
PSS000872 PGP000138
Fontanillas P et al. Nat Commun (2021)
Reported Trait: Melanoma OR: 1.33 [1.29, 1.37] AUROC: 0.579

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000871 Basal cell carcinoma cases were determined by a baseline survey containing 34 questions regarding personal history of skin cancer(including skin cancer type, age at diagnosis, body location, prescribed treatments and information regarding cancer recurrence)
[
  • 16,184 cases
  • , 72,740 controls
]
,
38.9 % Male samples
European 23andMe
PSS000872 Melanoma cases were determined by a baseline survey containing 34 questions regarding personal history of skin cancer(including skin cancer type, age at diagnosis, body location, prescribed treatments and information regarding cancer recurrence)
[
  • 4,179 cases
  • , 84,745 controls
]
,
38.9 % Male samples
European 23andMe
PSS000873 Squamous cell carcinoma cases were determined by a baseline survey containing 34 questions regarding personal history of skin cancer(including skin cancer type, age at diagnosis, body location, prescribed treatments and information regarding cancer recurrence)
[
  • 7,914 cases
  • , 81,010 controls
]
,
38.9 % Male samples
European 23andMe