PGS Publication: PGP000141

Publication Information (EuropePMC)
Title Genetic associations with temporal shifts in obesity and severe obesity during the obesity epidemic in Norway: A longitudinal population-based cohort (the HUNT Study).
PubMed ID 33315864(Europe PMC)
doi 10.1371/journal.pmed.1003452
Publication Date Dec. 14, 2020
Journal PLoS Med
Author(s) Brandkvist M, Bjørngaard JH, Ødegård RA, Brumpton B, Smith GD, Åsvold BO, Sund ER, Kvaløy K, Willer CJ, Vie GÅ.
Released in PGS Catalog: Feb. 23, 2021

Associated Polygenic Score(s)

External PGS Evaluated By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000027 GPS_BMI PGP000017
Khera AV et al. Cell (2019)
Body Mass Index body mass index 2,100,302 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000027/ScoringFiles/PGS000027.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001725 PGS000027
(GPS_BMI)
PSS000885 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity between male siblings OR: 2.21 [1.92, 2.54] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001726 PGS000027
(GPS_BMI)
PSS000886 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity within female siblings OR: 2.09 [1.74, 2.51] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001727 PGS000027
(GPS_BMI)
PSS000886 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity between female siblings OR: 2.13 [1.87, 2.43] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001728 PGS000027
(GPS_BMI)
PSS000887 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity within male siblings OR: 2.15 [1.91, 2.41] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001730 PGS000027
(GPS_BMI)
PSS000888 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity within female siblings OR: 1.87 [1.68, 2.09] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001731 PGS000027
(GPS_BMI)
PSS000888 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity between female siblings OR: 2.05 [1.89, 2.22] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001732 PGS000027
(GPS_BMI)
PSS000889 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity within male siblings OR: 2.0 [1.79, 2.23] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001733 PGS000027
(GPS_BMI)
PSS000889 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity between male siblings OR: 2.12 [1.96, 2.3] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001734 PGS000027
(GPS_BMI)
PSS000890 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity within female siblings OR: 2.0 [1.8, 2.21] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001735 PGS000027
(GPS_BMI)
PSS000890 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity between female siblings OR: 2.03 [1.88, 2.19] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001736 PGS000027
(GPS_BMI)
PSS000891 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity within male siblings OR: 1.9 [1.68, 2.14] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001737 PGS000027
(GPS_BMI)
PSS000891 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity between male siblings OR: 2.0 [1.83, 2.19] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001738 PGS000027
(GPS_BMI)
PSS000892 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity within female siblings OR: 1.72 [1.53, 1.93] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001739 PGS000027
(GPS_BMI)
PSS000892 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity between female siblings OR: 1.89 [1.74, 2.05] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001724 PGS000027
(GPS_BMI)
PSS000885 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity within male siblings OR: 2.02 [1.66, 2.46] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).
PPM001729 PGS000027
(GPS_BMI)
PSS000887 PGP000141
Brandkvist M et al. PLoS Med (2020)
Ext.
Reported Trait: Obesity between male siblings OR: 2.15 [1.97, 2.34] Sex, time of measurement, age, PCs (1-20), genotyping batch 2.07 million of the 2.1 milliion common variants (excluding those with insufficient quality of genotyping or imputation (r^2 < 0.8) in the HUNT cohort) were included in the polygenic score previously developed by Khera et al (2019).

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000892 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 17,740 cases
]
,
0.0 % Male samples
Mean = 58.9 years
Sd = 11.9 years
European HUNT number o cases = number of observations (more than 1 pp)
PSS000885 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 19,588 cases
]
,
100.0 % Male samples
Mean = 42.4 years
Sd = 12.6 years
European HUNT number o cases = number of observations (more than 1 pp)
PSS000886 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 21,499 cases
]
,
0.0 % Male samples
Mean = 42.6 years
Sd = 12.8 years
European HUNT number o cases = number of observations (more than 1 pp)
PSS000887 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 26,336 cases
]
,
100.0 % Male samples
Mean = 47.6 years
Sd = 16.1 years
European HUNT number o cases = number of observations (more than 1 pp)
PSS000888 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 29,545 cases
]
,
0.0 % Male samples
Mean = 47.1 years
Sd = 16.5 years
European HUNT number o cases = number of observations (more than 1 pp)
PSS000889 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 21,192 cases
]
,
100.0 % Male samples
Mean = 52.3 years
Sd = 14.5 years
European HUNT number o cases = number of observations (more than 1 pp)
PSS000890 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 25,108 cases
]
,
0.0 % Male samples
Mean = 51.2 years
Sd = 15.0 years
European HUNT number o cases = number of observations (more than 1 pp)
PSS000891 Body mass index (BMI) measurements were standardized with weight measured to the nearest half kilogram with the participants wearing light clothes and no shoes, and height was measured to the nearest centimeter. BMI was calculated using the formula weight in kilograms per meter squared. As defined by the World Health Organization (WHO), the authors rrefer to overweight as having BMI greater than or equal to 25 and obesity as having BMI greater than or equal to 30. Severe obesity was defined as having BMI greater than or equal to 35.
[
  • 14,487 cases
]
,
100.0 % Male samples
Mean = 60.2 years
Sd = 11.5 years
European HUNT number o cases = number of observations (more than 1 pp)