PGS Publication: PGP000143

Publication Information (EuropePMC)
Title Transethnic Transferability of a Genome-Wide Polygenic Score for Coronary Artery Disease.
PubMed ID 33284643(Europe PMC)
doi 10.1161/circgen.120.003092
Publication Date Dec. 7, 2020
Journal Circ Genom Precis Med
Author(s) Fahed AC, Aragam KG, Hindy G, Chen YI, Chaudhary K, Dobbyn A, Krumholz HM, Sheu WHH, Rich SS, Rotter JI, Chowdhury R, Cho J, Do R, Ellinor PT, Kathiresan S, Khera AV.
Released in PGS Catalog: Feb. 23, 2021

Associated Polygenic Score(s)

External PGS Evaluated By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000013 GPS_CAD PGP000006
Khera AV et al. Nat Genet (2018)
Coronary artery disease coronary artery disease 6,630,150 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000013/ScoringFiles/PGS000013.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001746 PGS000013
(GPS_CAD)
PSS000898 PGP000143
Fahed AC et al. Circ Genom Precis Med (2020)
Ext.
Reported Trait: Coronary artery disease OR: 1.25 [1.12, 1.4] PCs(1-4)
PPM001747 PGS000013
(GPS_CAD)
PSS000902 PGP000143
Fahed AC et al. Circ Genom Precis Med (2020)
Ext.
Reported Trait: Coronary artery disease OR: 1.47 [1.36, 1.59] PCs(1-4)
PPM001749 PGS000013
(GPS_CAD)
PSS000901 PGP000143
Fahed AC et al. Circ Genom Precis Med (2020)
Ext.
Reported Trait: Coronary artery disease OR: 1.52 [1.43, 1.62] PCs(1-4)
PPM001745 PGS000013
(GPS_CAD)
PSS000900 PGP000143
Fahed AC et al. Circ Genom Precis Med (2020)
Ext.
Reported Trait: Coronary artery disease OR: 1.6 [1.44, 1.78] PCs(1-4)
PPM001748 PGS000013
(GPS_CAD)
PSS000899 PGP000143
Fahed AC et al. Circ Genom Precis Med (2020)
Ext.
Reported Trait: Coronary artery disease OR: 1.66 [1.47, 1.86] PCs(1-4)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000898 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 1,370 cases
  • , 15,385 controls
]
African unspecified BMBB, MESA, PHB, UKB, VIRGO
PSS000899 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 435 cases
  • , 3,553 controls
]
East Asian TaiChi, UKB
PSS000900 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 26,462 cases
  • , 448,036 controls
]
European BMBB, MESA, PHB, UKB, VIRGO
PSS000901 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 1,224 cases
  • , 7,861 controls
]
Hispanic or Latin American BMBB, MESA, PHB, VIRGO
PSS000902 Coronary artery disease was defined as myocardial infarction and/or history of coronary revascularization.
[
  • 874 cases
  • , 7,228 controls
]
South Asian BRAVE, UKB