Publication Information (EuropePMC) | |
Title | Whole genome sequencing in the Middle Eastern Qatari population identifies genetic associations with 45 clinically relevant traits. |
PubMed ID | 33623009(Europe PMC) |
doi | 10.1038/s41467-021-21381-3 |
Publication Date | Feb. 23, 2021 |
Journal | Nat Commun |
Author(s) | Thareja G, Al-Sarraj Y, Belkadi A, Almotawa M, Qatar Genome Program Research (QGPR) Consortium, Suhre K, Albagha OME. |
Polygenic Score (PGS) ID | PGS Name | PGS Publication (PGP) ID | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | PGS Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS000167 | hct | PGP000078 Vuckovic D et al. Cell (2020) |
Hematocrit | hematocrit | 502 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000167/ScoringFiles/PGS000167.txt.gz |
PGS000168 | hgb | PGP000078 Vuckovic D et al. Cell (2020) |
Hemoglobin concentration | hemoglobin measurement | 515 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000168/ScoringFiles/PGS000168.txt.gz |
PGS000297 | GRS3290_Height | PGP000092 Xie T et al. Circ Genom Precis Med (2020) |
Height | body height | 3,290 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000297/ScoringFiles/PGS000297.txt.gz |
PGS000187 | rbc | PGP000078 Vuckovic D et al. Cell (2020) |
Red blood cell count | erythrocyte count | 678 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000187/ScoringFiles/PGS000187.txt.gz |
PGS000174 | mch | PGP000078 Vuckovic D et al. Cell (2020) |
Mean corpuscular hemoglobin | mean corpuscular hemoglobin | 628 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000174/ScoringFiles/PGS000174.txt.gz |
PGS000175 | mchc | PGP000078 Vuckovic D et al. Cell (2020) |
Mean corpuscular hemoglobin concentration | mean corpuscular hemoglobin concentration | 224 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000175/ScoringFiles/PGS000175.txt.gz |
PGS000176 | mcv | PGP000078 Vuckovic D et al. Cell (2020) |
Mean corpuscular volume | mean corpuscular volume | 685 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000176/ScoringFiles/PGS000176.txt.gz |
PGS000179 | mpv | PGP000078 Vuckovic D et al. Cell (2020) |
Mean platelet volume | mean platelet volume | 654 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000179/ScoringFiles/PGS000179.txt.gz |
PGS000186 | plt | PGP000078 Vuckovic D et al. Cell (2020) |
Platelet count | platelet count | 739 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000186/ScoringFiles/PGS000186.txt.gz |
PGS000027 | GPS_BMI | PGP000017 Khera AV et al. Cell (2019) |
Body Mass Index | body mass index | 2,100,302 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000027/ScoringFiles/PGS000027.txt.gz |
PGS000191 | wbc | PGP000078 Vuckovic D et al. Cell (2020) |
White blood cell count | leukocyte count | 636 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000191/ScoringFiles/PGS000191.txt.gz |
PGS Performance Metric ID (PPM ID) |
Evaluated Score |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM001777 | PGS000167 (hct) |
PSS000911 | PGP000147 Thareja G et al. Nat Commun (2021) Ext. |
Reported Trait: Hematocrit | — | — | Pearson correlation coefficent (r): 0.15 | — | — |
PPM001778 | PGS000168 (hgb) |
PSS000911 | PGP000147 Thareja G et al. Nat Commun (2021) Ext. |
Reported Trait: Hemoglobin | — | — | Pearson correlation coefficent (r): 0.14 | — | — |
PPM001775 | PGS000186 (plt) |
PSS000911 | PGP000147 Thareja G et al. Nat Commun (2021) Ext. |
Reported Trait: Platelet count | — | — | Pearson correlation coefficent (r): 0.35 | — | — |
PPM001776 | PGS000179 (mpv) |
PSS000911 | PGP000147 Thareja G et al. Nat Commun (2021) Ext. |
Reported Trait: Mean platelet volume | — | — | Pearson correlation coefficent (r): 0.51 | — | — |
PPM001768 | PGS000297 (GRS3290_Height) |
PSS000911 | PGP000147 Thareja G et al. Nat Commun (2021) Ext. |
Reported Trait: Height | — | — | Pearson correlation coefficent (r): 0.15 | — | — |
PPM001769 | PGS000027 (GPS_BMI) |
PSS000911 | PGP000147 Thareja G et al. Nat Commun (2021) Ext. |
Reported Trait: Body mass index | — | — | Pearson correlation coefficent (r): 0.22 | — | — |
PPM001770 | PGS000191 (wbc) |
PSS000911 | PGP000147 Thareja G et al. Nat Commun (2021) Ext. |
Reported Trait: White blood cell count | — | — | Pearson correlation coefficent (r): 0.19 | — | — |
PPM001771 | PGS000187 (rbc) |
PSS000911 | PGP000147 Thareja G et al. Nat Commun (2021) Ext. |
Reported Trait: Red blood cell count | — | — | Pearson correlation coefficent (r): 0.22 | — | — |
PPM001772 | PGS000175 (mchc) |
PSS000911 | PGP000147 Thareja G et al. Nat Commun (2021) Ext. |
Reported Trait: Mean cell hemoglobin concentration | — | — | Pearson correlation coefficent (r): 0.12 | — | — |
PPM001773 | PGS000174 (mch) |
PSS000911 | PGP000147 Thareja G et al. Nat Commun (2021) Ext. |
Reported Trait: Mean corpuscular hemoglobin | — | — | Pearson correlation coefficent (r): 0.22 | — | — |
PPM001774 | PGS000176 (mcv) |
PSS000911 | PGP000147 Thareja G et al. Nat Commun (2021) Ext. |
Reported Trait: Mean corpuscular volume | — | — | Pearson correlation coefficent (r): 0.23 | — | — |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000911 | — | — | 13,989 individuals | — | Greater Middle Eastern (Middle Eastern, North African or Persian) (Qatari) |
— | QBB | — |