PGS Publication: PGP000153

Publication Information (EuropePMC)
Title A Polygenic Risk Score as a Risk Factor for Medication-Associated Fractures.
PubMed ID 32511779(Europe PMC)
doi 10.1002/jbmr.4104
Publication Date July 20, 2020
Journal J Bone Miner Res
Author(s) Manousaki D, Forgetta V, Keller-Baruch J, Zhao K, Greenwood CM, Mooser V, Bassett JD, Leslie WD, Richards JB.
Released in PGS Catalog: March 22, 2021

Associated Polygenic Score(s)

External PGS Evaluated By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000657 gSOS PGP000120
Forgetta V et al. PLoS Med (2020)
Heel quantitative ultrasound speed of sound (SOS) calcaneal bone quantitative ultrasound measurement 21,717 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000657/ScoringFiles/PGS000657.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001852 PGS000657
(gSOS)
PSS000937 PGP000153
Manousaki D et al. J Bone Miner Res (2020)
Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.69 [0.65, 0.71]
PPM001853 PGS000657
(gSOS)
PSS000937 PGP000153
Manousaki D et al. J Bone Miner Res (2020)
Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.68 [0.64, 0.73] Odds ratio (OR, bottom 50% vs top 50%): 1.86 [1.62, 2.13] Baseline fracture risk (FRAX), fracture-related drug use, fracture-related drug use*gSOS
PPM001854 PGS000657
(gSOS)
PSS000936 PGP000153
Manousaki D et al. J Bone Miner Res (2020)
Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.67, 0.87] Odds ratio (OR, bottom 50% vs top 50%): 1.42 [1.08, 1.88] Basline fracture risk (FRAX), fracture-related drug use
PPM001855 PGS000657
(gSOS)
PSS000936 PGP000153
Manousaki D et al. J Bone Miner Res (2020)
Ext.
Reported Trait: Incident hip fracture OR: 0.74 [0.64, 0.78]
PPM001856 PGS000657
(gSOS)
PSS000936 PGP000153
Manousaki D et al. J Bone Miner Res (2020)
Ext.
Reported Trait: Incident hip fracture OR: 0.76 [0.64, 0.89] Baseline fracture risk (FRAX), fracture-related drug use, fracture-related drug use*gSOS
PPM001857 PGS000657
(gSOS)
PSS000933 PGP000153
Manousaki D et al. J Bone Miner Res (2020)
Ext.
Reported Trait: Incident major osteoporotic fracture in fracture-related drug users OR: 0.78 [0.68, 0.88] Odds ratio (OR, bottom 50% vs top 50%): 1.54 [1.19, 1.99] Basline fracture risk (FRAX)
PPM001858 PGS000657
(gSOS)
PSS000932 PGP000153
Manousaki D et al. J Bone Miner Res (2020)
Ext.
Reported Trait: incident hip fracture in fracture-related drug users OR: 0.77 [0.61, 0.98] Odds ratio (OR, bottom 50% vs top 50%): 1.99 [1.19, 3.31] Basline fracture risk (FRAX)
PPM001859 PGS000657
(gSOS)
PSS000935 PGP000153
Manousaki D et al. J Bone Miner Res (2020)
Ext.
Reported Trait: Incident major osteoporotic fracture in individuals who don’t use fracture-related drugs OR: 0.57 [0.54, 0.61] Odds ratio (OR, bottom 50% vs top 50%): 1.75 [1.65, 1.86] Basline fracture risk (FRAX)
PPM001860 PGS000657
(gSOS)
PSS000934 PGP000153
Manousaki D et al. J Bone Miner Res (2020)
Ext.
Reported Trait: Incident hip fracture in individuals who don’t use fracture-related drugs OR: 0.36 [0.3, 0.43] Odds ratio (OR, bottom 50% vs top 50%): 2.81 [2.35, 3.36] Basline fracture risk (FRAX)
PPM001851 PGS000657
(gSOS)
PSS000937 PGP000153
Manousaki D et al. J Bone Miner Res (2020)
Ext.
Reported Trait: Incident major osteoporotic fracture OR: 0.7 [0.66, 0.75] Odds Ratio (OR, bottom 50% vs top 50%): 1.79 [1.58, 2.01] Basline fracture risk (FRAX), fracture-related drug use

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000932 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320
[
  • 68 cases
  • , 12,610 controls
]
,
40.52 % Male samples
Mean = 58.6 years
Sd = 7.7 years
European UKB
PSS000933 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320
[
  • 256 cases
  • , 12,422 controls
]
,
40.52 % Male samples
Mean = 58.6 years
Sd = 7.6 years
European UKB
PSS000934 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S322
[
  • 141 cases
  • , 67,195 controls
]
,
46.27 % Male samples
Mean = 56.5 years
Sd = 8.2 years
European UKB
PSS000935 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S321
[
  • 933 cases
  • , 66,403 controls
]
,
46.27 % Male samples
Mean = 56.5 years
Sd = 8.1 years
European UKB
PSS000936 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320
[
  • 209 cases
  • , 79,805 controls
]
,
45.36 % Male samples
Mean = 56.8 years
Sd = 8.1 years
European UKB
PSS000937 Incident major osteoporotic fractures (MOF; composite of hip, clinical spine, forearm, humerus)(16) were identified from ques- tionnaire data from UK Biobank from the baseline assessment and ICD-10 codes from hospital admissions (primary diagnoses). ICD codes used to identify Fracture cases include: M8002, M8003, M8082, M8083, S422, S423, S424, S520, S521, S522, S523, S525, S526, S529, M8005, M8085, S720, S721,S722, M8008, M8088, S220, S320
[
  • 1,189 cases
  • , 78,825 controls
]
,
45.36 % Male samples
Mean = 56.8 years
Sd = 8.0 years
European UKB