PGS Publication: PGP000157

Publication Information (EuropePMC)
Title Genetic Predictor to Identify Individuals With High Lipoprotein(a) Concentrations.
PubMed ID 33522245(Europe PMC)
doi 10.1161/circgen.120.003182
Publication Date Feb. 1, 2021
Journal Circ Genom Precis Med
Author(s) Dron JS, Wang M, Patel AP, Kartoun U, Ng K, Hegele RA, Khera AV.
Released in PGS Catalog: March 22, 2021

Associated Polygenic Score(s)

PGS Developed By This Publication

Polygenic Score (PGS) ID PGS Name PGS Publication (PGP) ID Reported Trait Mapped Trait(s) (Ontology) Number of Variants PGS Scoring File (FTP Link)
PGS000752 PGS_Lpa PGP000157
Dron JS et al. Circ Genom Precis Med (2021)
Lipoprotein(a) concentration [nmol/L] lipoprotein A measurement 11,446 http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000752/ScoringFiles/PGS000752.txt.gz

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
Evaluated Score PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM001911 PGS000752
(PGS_Lpa)
PSS000954 PGP000157
Dron JS et al. Circ Genom Precis Med (2021)
Reported Trait: Lipoprotein(a) concentration [nmol/L] Pearson correlation coefficient (r): 0.5

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000954 43,071 individuals European UKB