Publication Information (EuropePMC) | |
Title | Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups. |
PubMed ID | 33536424(Europe PMC) |
doi | 10.1038/s41467-021-21049-y |
Publication Date | Feb. 3, 2021 |
Journal | Nat Commun |
Author(s) | Wang YF, Zhang Y, Lin Z, Zhang H, Wang TY, Cao Y, Morris DL, Sheng Y, Yin X, Zhong SL, Gu X, Lei Y, He J, Wu Q, Shen JJ, Yang J, Lam TH, Lin JH, Mai ZM, Guo M, Tang Y, Chen Y, Song Q, Ban B, Mok CC, Cui Y, Lu L, Shen N, Sham PC, Lau CS, Smith DK, Vyse TJ, Zhang X, Lau YL, Yang W. |
Polygenic Score (PGS) ID | PGS Name | PGS Publication (PGP) ID | Reported Trait | Mapped Trait(s) (Ontology) | Number of Variants | PGS Scoring File (FTP Link) |
---|---|---|---|---|---|---|
PGS000754 | PRS_SLE | PGP000160 Wang YF et al. Nat Commun (2021) |
Systemic lupus erythrmatosus | systemic lupus erythematosus | 293,684 | http://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000754/ScoringFiles/PGS000754.txt.gz |
PGS Performance Metric ID (PPM ID) |
Evaluated Score |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|---|
PPM001919 | PGS000754 (PRS_SLE) |
PSS000963 | PGP000160 Wang YF et al. Nat Commun (2021) |
Reported Trait: Systemic lupus erythematosus | — | AUROC: 0.76 [0.74, 0.78] | — | — | — |
PPM001920 | PGS000754 (PRS_SLE) |
PSS000960 | PGP000160 Wang YF et al. Nat Commun (2021) |
Reported Trait: Systemic lupus erythematosus | — | AUROC: 0.65 | — | — | — |
PPM001921 | PGS000754 (PRS_SLE) |
PSS000961 | PGP000160 Wang YF et al. Nat Commun (2021) |
Reported Trait: Systemic lupus erythematosus | — | AUROC: 0.65 | — | — | — |
PPM001922 | PGS000754 (PRS_SLE) |
PSS000962 | PGP000160 Wang YF et al. Nat Commun (2021) |
Reported Trait: Systemic lupus erythematosus | — | AUROC: 0.62 | — | — | — |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000960 | Cases were individuals with systemic lupus erythematosus. | — | [
|
— | European | — | — | |
PSS000961 | Cases were individuals with systemic lupus erythematosus. | — | [
|
— | European | — | — | |
PSS000962 | Cases were individuals with systemic lupus erythematosus. | — | [
|
— | European | — | — | |
PSS000963 | Cases were individuals with systemic lupus erythematosus. | — | [
|
— | East Asian (Han Chinese) |
— | — |