PGS Publication: PGP000708

Publication Information (EuropePMC)
Title Binge-pattern alcohol consumption and genetic risk as determinants of alcohol-related liver disease.
PubMed ID 38097541(Europe PMC)
doi 10.1038/s41467-023-43064-x
Publication Date Dec. 14, 2023
Journal Nat Commun
Author(s) Ding C, Ng Fat L, Britton A, Im PK, Lin K, Topiwala A, Li L, Chen Z, Millwood IY, Bell S, Mehta G.
Released in PGS Catalog: Feb. 26, 2025

Associated Polygenic Score(s)

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Individuals included in:
G - Source of Variant Associations (GWAS)
D - Score Development/Training
E - PGS Evaluation
List of ancestries includes:
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Additional Diverse Ancestries
Not Reported

External PGS Evaluated By This Publication

Polygenic Score ID & Name PGS Publication ID (PGP) Reported Trait Mapped Trait(s) (Ontology) Number of Variants Ancestry distribution
GWAS
Dev
Eval
 Scoring File (FTP Link)
PGS000704
(HC171)
 PGP000128 |
Sinnott-Armstrong N et al. Nat Genet (2021)
 Alcoholic cirrhosis alcoholic liver cirrhosis 183,271
-
 https://ftp.ebi.ac.uk/pub/databases/spot/pgs/scores/PGS000704/ScoringFiles/PGS000704.txt.gz - Check Terms/Licenses

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		Evaluated Score PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM022382 PGS000704
(HC171)
 PSS011933|
Multi-ancestry (including European)|
312,599 individuals
 PGP000708 |
Ding C et al. Nat Commun (2023)
|Ext.		 Reported Trait: Alcohol-related cirrhosis HR: 1.67 [1.55, 1.8] — — sex, age, ethnicity, Townsend deprivation index at recruitment, physical activity, smoking, total weekly alcohol intake, beverage type, drinking with/without meal, daily alcohol consumption group, diabetes, BMI, first 10 principal genetic components, and genotyping array —
PPM022383 PGS000704
(HC171)
 PSS011933|
Multi-ancestry (including European)|
312,599 individuals
 PGP000708 |
Ding C et al. Nat Commun (2023)
|Ext.		 Reported Trait: Alcoholic hepatitis HR: 1.32 [1.12, 1.57] — — sex, age, ethnicity, Townsend deprivation index at recruitment, physical activity, smoking, total weekly alcohol intake, beverage type, drinking with/without meal, daily alcohol consumption group, diabetes, BMI, first 10 principal genetic components, and genotyping array —
PPM022384 PGS000704
(HC171)
 PSS011933|
Multi-ancestry (including European)|
312,599 individuals
 PGP000708 |
Ding C et al. Nat Commun (2023)
|Ext.		 Reported Trait: Alcohol-related cirrhosis x alcohol consumption interaction — — Hazard ratio (HR, heavy binge drinking and high PRS vs. below daily limit drinking and low PRS): 12.41 [4.96, 31.05] total weekly alcohol intake, diabetes, BMI, sex, age, ethnicity, Townsend deprivation index, physical activity, smoke, alcohol type, drinking with/without meals, genotyping array, and first 10 ancestry principal components —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS011933 — — 294,816 individuals — European — UKB —
PSS011933 — — 17,783 individuals — Not reported — UKB —