Polygenic Score (PGS) ID: PGS000010

Predicted Trait
Reported Trait Coronary heart disease
Mapped Trait(s) coronary heart disease (EFO_0001645)
Released in PGS: Oct. 14, 2019

Score Details

Score Construction
PGS Name GRS27
Variants
Original Genome Build NR
Number of Variants 27
Development Method
Name Genome-wide significant SNPs
Parameters NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000003
Citation (link to publication) Mega JL et al. Lancet (2015)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST000998
[
  • 22,233 cases
  • , 64,762 controls
]
European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000014 PSS000008 PGP000003
Mega JL et al. (2015)
Reported Trait: Coronary heart disease HR: 1.21[1.17, 1.26] age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes
PPM000015 PSS000009 PGP000003
Mega JL et al. (2015)
Reported Trait: Coronary heart disease HR: 1.14[1.02, 1.28] age, sex, diabetes status, smoking, race, family history of coronary heart disease, HDL cholesterol, LDL cholesterol, and hypertension Meta-analysis of sub-cohort effect sizes
PPM000017 PSS000010 PGP000004
Tada H et al. (2015)
Ext.
Reported Trait: Incident coronary heart disease HR: 1.2[1.15, 1.25] age, sex, systolic blood pressure, hypertension treatment, smoking, apoB, apoA-I, prevalent diabetes
PPM000019 PSS000012 PGP000005
Abraham G et al. (2016)
Ext.
Reported Trait: Incident coronary artery disease HR: 1.21[1.12, 1.3]
PPM000021 PSS000011 PGP000005
Abraham G et al. (2016)
Ext.
Reported Trait: Incident coronary artery disease HR: 1.2[1.07, 1.26]

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 149 cases
  • , 6,829 controls
]
,
79.7 % Male samples
European ASCOT Primary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 320 cases
  • , 2,558 controls
]
,
86.1 % Male samples
European CARE_b Secondary prevention cohorts
PSS000009 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 229 cases
  • , 1,770 controls
]
,
77.5 % Male samples
European PROVEIT Secondary prevention cohorts
PSS000010 Incident CHD was defined as coronary revascularization, fatal or nonfatal myocardial infarction, or death due to ischemic heart disease.
[
  • 2,213 cases
  • , 21,382 controls
]
,
38.03 % Male samples
European
(Swedish)
MDC Prospective study
PSS000011 The main outcome of interest was incident CHD event before age 75y. We used the definition of CHD as employed by the Framingham study, namely, one of • MI recognized, with diagnostic ECG (FHS event code #1) • MI recognized, without diagnostic ECG, with enzymes and history (#2) • MI recognized, without diagnostic ECG, with autopsy evidence (new event) (#3) • MI unrecognized, silent (#4) • MI unrecognized, not silent (#5) • Angina pectoris (AP), first episode only (#6) • Coronary insufficiency (CI), definite by both history and ECG (#7) • Questionable MI at exam 1 (#8) • Acute MI by autopsy, previously coded as 1 or 2 (#9) • Death, CHD sudden, with 1 hour (#21) • Death, CHD 1–23 hours, non sudden (#22) • Death, CHD 24-47 hours, non sudden (#23) • Death, CHD, 48 hours or more, non sudden (#24)
[
  • 587 cases
  • , 2,819 controls
]
,
45.0 % Male samples
European FHS FHS Original, FHS Offspring
PSS000012 Coronary heart disease (CHD) was defined as falling into any of the following categories: • I21 or I22 (ICD-10) / 410 (ICD-8/9) as the direct or as a contributing cause of death or I20-I25 (ICD-10) /410-414 (ICD-9) as the underlying cause of death • I21 or I22 (ICD-10) / 410 (ICD-8/9) as the main or secondary diagnosis at hospital discharge. • Coronary bypass surgery or coronary angioplasty at hospital discharge or identified from the Finnish registry of invasive cardiac procedures.
[
  • 757 cases
  • , 11,919 controls
]
,
46.0 % Male samples
European
(Finnish)
FINRISK FR92, FR97, FR02
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention 27,271 individuals,
38.7 % Male samples
European
(Swedish)
MDC Primary prevention cohorts
PSS000008 Coronary heart disease represented a composite of fatal or non-fatal myocardial infarction, coronary artery bypass grafting, or percutaneous coronary intervention
[
  • 108 cases
  • , 8,641 controls
]
,
67.8 % Male samples
European JUPITER Primary prevention cohorts