| Predicted Trait | |
| Reported Trait | Coronary artery disease |
| Mapped Trait(s) | coronary artery disease (EFO_0000378) |
| Score Construction | |
| PGS Name | metaGRS_CAD |
| Variants | |
| Original Genome Build | hg19 |
| Number of Variants | 1,745,180 |
| Development Method | |
| Name | metaGRS |
| Parameters | metaGRS log(HR) mixing weights: GRS46K=0.1278, FDR202=0.2359 and 1000Genomes=0.2400 |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000007 |
| Citation (link to publication) | Inouye M et al. J Am Coll Cardiol (2018) |
| Study Identifiers | Sample Numbers | Sample Ancestry |
|---|---|---|
| GWAS Catalog: GCST003116 EuropePMC: 26343387 |
11,323 individuals | East Asian |
| GWAS Catalog: GCST003116 EuropePMC: 26343387 |
25,557 individuals | South Asian |
| GWAS Catalog: GCST003116 EuropePMC: 26343387 |
2,268 individuals | Greater Middle Eastern (Middle Eastern, North African or Persian) |
| GWAS Catalog: GCST003116 EuropePMC: 26343387 |
4,095 individuals | Hispanic or Latin American |
| GWAS Catalog: GCST003116 EuropePMC: 26343387 |
141,217 individuals | European |
| GWAS Catalog: GCST003116 EuropePMC: 26343387 |
3,139 individuals | African American or Afro-Caribbean |
| EuropePMC: 23202125 | [
|
Other |
| Detailed Phenotype Description | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|
| CAD was defined as fatal or nonfatal myocardial infarction (MI) cases, percutaneous transluminal coronary angioplasty (PTCA), or coronary artery bypass grafting (CABG). Prevalent versus incident status was relative to the UKB enrollment assessment. In UKB self-reported data, cases were defined as having had a heart attack diagnosed by a doctor (data field #6150); “non-cancer illnesses that self-reported as heart attack” (data field #20002); or self-reported operation including PTCA, CABG, or triple heart bypass (data field #20004). In HES hospital episodes data and death registry data, MI was defined as hospital admission or cause of death due to ICD-9 410 to 412, or ICD-10 I21 to I24 or I25.2; CABG and PTCA were defined as hospital admission OPCS-4 K40 to K46, K49, K50.1,or K75. | — | [
|
— | Other | ~95% European ancestry samples, <5% non-European ancestry | UKB | — |
Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
|
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM000027 | PSS000018 | PGP000007 Inouye M et al. (2018) |
Reported Trait: Incident coronary artery disease | HR: 1.706[1.682, 1.73] | AUROC: 0.79 C-index: 0.623[0.615, 0.631] |
AUPRC: 0.161 | sex, genetic PCs (1-10), genotyping array | age-as-time-scale Cox regression |
| PPM000034 | PSS000021 | PGP000008 Wünnemann F et al. (2019) Ext. |
Reported Trait: Coronary artery disease (prevalent) | OR: 1.74[1.57, 1.93] | AUROC: 0.72[0.7, 0.75] | — | age, sex, first four genetic PCs | — |
| PPM000035 | PSS000022 | PGP000008 Wünnemann F et al. (2019) Ext. |
Reported Trait: Coronary artery disease (prevalent) | OR: 1.6[1.43, 1.8] | AUROC: 0.89[0.88, 0.91] | — | age, sex, first four genetic PCs | — |
| PPM000036 | PSS000019 | PGP000008 Wünnemann F et al. (2019) Ext. |
Reported Trait: Coronary artery disease (prevalent) | OR: 1.75[1.49, 2.05] | AUROC: 0.84[0.81, 0.87] | — | age, sex, first four genetic PCs, cohort recruitment centre | — |
| PPM000037 | PSS000020 | PGP000008 Wünnemann F et al. (2019) Ext. |
Reported Trait: Reccurent coronary artery disease events | OR: 1.17[1.08, 1.26] | — | — | age, sex, first four genetic PCs | — |
| PPM000518 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Plaque vulnerability score | β: 0.07[0.003, 0.137] | — | — | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000517 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Microvessels | β: 0.037[-0.006, 0.08] | — | — | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000516 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Number of smoooth muscle cells | β: -0.004[-0.038, 0.031] | — | — | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000515 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Number of macrophages | β: 0.01[-0.015, 0.036] | — | — | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000514 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Moderate/heavy macrophages | OR: 1.103[0.983, 1.237] | — | — | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000513 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Moderate/heavy smooth muscle cells | OR: 1.004[0.88, 1.145] | — | — | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000512 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Presence of IPH | OR: 1.126[0.999, 1.27] | — | — | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000511 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Presence of lipid core >10% | OR: 1.171[1.026, 1.337] | — | — | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000510 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Moderate/heavy collagen | OR: 1.064[0.919, 1.231] | — | — | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000509 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Moderate/heavy calficiations | OR: 0.94[0.826, 1.07] | — | — | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000508 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Plaque vulnerability score | OR: 0.198[0.003, 0.364] | — | — | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000507 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Microvessels | — | — | Beta (top 20% vs. rest): 0.072[-0.037, 0.182] | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000506 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Number of smoooth muscle cells | — | — | Beta (top 20% vs. rest): -0.056[-0.143, 0.031] | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000505 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Number of macrophages | — | — | Beta (top 20% vs. rest): 0.55[-0.012, 0.121] | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000504 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Moderate/heavy macrophages | — | — | Odds Ratio (OR; top 20% vs. rest): 1.49[1.118, 1.986] | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000503 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Moderate/heavy smooth muscle cells | — | — | Odds Ratio (OR; top 20% vs. rest): 0.908[0.652, 1.265] | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000502 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Presence of IPH | — | — | Odds Ratio (OR; top 20% vs. rest): 1.112[0.821, 1.506] | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000501 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Presence of lipid core >10% | — | — | Odds Ratio (OR; top 20% vs. rest): 1.591[1.105, 2.291] | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000500 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Moderate/heavy collagen | — | — | Odds Ratio (OR; top 20% vs. rest): 1.091[0.755, 1.577] | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000499 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Moderate/heavy calficiations | — | — | Odds Ratio (OR; top 20% vs. rest): 1.001[0.754, 1.33] | Age, sex, surgery year, type of cerebrovascular symptoms, array, 4 genetic PCs | — |
| PPM000498 | PSS000287 | PGP000077 Timmerman N et al. (2019) Ext. Pre |
Reported Trait: Secondary cardiovascular events | HR: 1.15[1.02, 1.29] | — | — | Age, sex, diabetes, BMI, smoking, hypercholesterolemia, array, 4 genetics PCs | — |
|
PGS Sample Set ID (PSS ID) |
Detailed Phenotype Description | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000287 | (i) Secondary cardiovascular events (sCVE; incl myocardial infarction, stroke, ruptured abdominal aortic aneurysm, fatal cardiac failure, percuteneous of bypass surgery, leg amputation due to cardiovascular causes, cardiovascular death), (ii) atherosclerotic carotid plaque characteristics | Mean = 3.0 years | 1,319 individuals, 69.3 % Male samples |
Mean = 68.8 years Sd = 9.3 years |
European (Dutch) |
— | AEGS1 | — |
| PSS000018 | CAD was defined as fatal or nonfatal myocardial infarction (MI) cases, percutaneous transluminal coronary angioplasty (PTCA), or coronary artery bypass grafting (CABG). Prevalent versus incident status was relative to the UKB enrollment assessment. In UKB self-reported data, cases were defined as having had a heart attack diagnosed by a doctor (data field #6150); “non-cancer illnesses that self-reported as heart attack” (data field #20002); or self-reported operation including PTCA, CABG, or triple heart bypass (data field #20004). In HES hospital episodes data and death registry data, MI was defined as hospital admission or cause of death due to ICD-9 410 to 412, or ICD-10 I21 to I24 or I25.2; CABG and PTCA were defined as hospital admission OPCS-4 K40 to K46, K49, K50.1,or K75. | — | [ ,
45.6 % Male samples |
— | Other | ~95% European ancestry samples, <5% non-European ancestry | UKB | — |
| PSS000019 | Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). | — | [ ,
41.29 % Male samples |
— | European (French Canadian) |
— | CARTaGENE | — |
| PSS000020 | Recurrent CAD event during the follow- up period (median follow-up time =3.9 years [range =1.1–7), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). | — | [
|
— | European (French Canadian) |
— | MHI | Phase 1 |
| PSS000020 | Recurrent CAD event during the follow- up period (median follow-up time =3.9 years [range =1.1–7), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). | — | [
|
— | European (French Canadian) |
— | MHI | Phase 2 |
| PSS000021 | Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). | — | [ ,
72.7 % Male samples |
— | European (French Canadian) |
— | MHI | Phase 1 |
| PSS000022 | Prevalent Coronary artery disease (CAD), where CAD is defined as previous diagnosis of myocardial infarction or revascularization procedures (percutaneous coronary intervention or coronary artery bypass grafting). | — | [ ,
72.38 % Male samples |
— | European (French Canadian) |
— | MHI | Phase 2 |