Polygenic Score (PGS) ID: PGS000020

Predicted Trait
Reported Trait Type 2 diabetes
Mapped Trait(s) type II diabetes mellitus (EFO_0001360)
Released in PGS Catalog: Oct. 14, 2019
Download Score FTP directory
Terms and Licenses
PGS obtained from the Catalog should be cited appropriately, and used in accordance with any licensing restrictions set by the authors. See EBI Terms of Use (https://www.ebi.ac.uk/about/terms-of-use/) for additional details.

Score Details

Score Construction
PGS Name dGRS1000
Original Genome Build NCBI36
Number of Variants 7,502
Development Method
Name P+T
Parameters P < 0.05, r2 < 0.05, betas are weighted by the probability that they are in the top 1000 signals
PGS Source
PGS Catalog Publication (PGP) ID PGP000010
Citation (link to publication) Läll K et al. Genet Med (2016)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST005047
EuropePMC: 22885922
69,033 individuals European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000040 PSS000025 PGP000010
Läll K et al. Genet Med (2016)
Reported Trait: Incident type 2 diabetes HR: 1.48 [1.32, 1.66] C-index: 0.79 [0.771, 0.812] BMI category, smoking level, waist-to-hip ratio, waist circumference, physical activity level, history of high blood glucose, fruit and vegetable consumption, and sex. Cox age-as-time-scale

Evaluated Samples

PGS Sample Set ID
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000025 Incident cases of Type 2 Diabetes in 5.63 years follow-up
  • 302 cases
  • , 5,978 controls
55.0 % Male samples