Polygenic Score (PGS) ID: PGS000024

Predicted Trait
Reported Trait Type 1 diabetes
Mapped Trait(s) type I diabetes mellitus (EFO_0001359)
Released in PGS: Oct. 14, 2019

Score Details

Score Construction
PGS Name GRS2
Variants
Original Genome Build NR
Number of Variants 67
Number of Variant Interaction Terms 18
Development Method
Name Genome-wide significant associations and interaction modelling
Parameters Significance threshold for interactions: p < 10^-4
PGS Source
PGS Catalog Publication (PGP) ID PGP000014
Citation (link to publication) Sharp SA et al. Diabetes Care (2019)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST000392
EuropePMC: 19956093
[
  • 6,670 cases
  • , 9,416 controls
]
European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000048 PSS000032 PGP000014
Sharp SA et al. (2019)
Reported Trait: Type 1 diabetes AUROC: 0.921 Youden index: 0.698

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000032 Type 1 Diabetes Case Definition = Clinical diagnosis of diabetes at less than or equal to 20 years of age; On insulin within 1 year from the time of diagnosis; Still on insulin at the time of recruit- ment; Not using oral antihyperglycemic agents; Did not ever self-report as having type 2 diabetes (T2D)
[
  • 387 cases
  • , 373,613 controls
]
European UKB