| Predicted Trait | |
| Reported Trait | Body Mass Index |
| Mapped Trait(s) | body mass index (EFO_0004340) |
| Score Construction | |
| PGS Name | GPS_BMI |
| Variants | |
| Original Genome Build | hg19 |
| Number of Variants | 2,100,302 |
| Development Method | |
| Name | LDpred |
| Parameters | ρ = 0.03; LD reference panel = 503 European samples from 1000 Genomes phase 3 |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000017 |
| Citation (link to publication) | Khera AV et al. Cell (2019) |
| Study Identifiers | Sample Numbers | Sample Ancestry |
|---|---|---|
| GWAS Catalog: GCST002783 EuropePMC: 25673413 |
236,781 individuals | European |
| GWAS Catalog: GCST002783 EuropePMC: 25673413 |
887 individuals | African American or Afro-Caribbean |
| GWAS Catalog: GCST002783 EuropePMC: 25673413 |
1,276 individuals | Hispanic or Latin American |
| Detailed Phenotype Description | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|
| — | — | 119,951 individuals | — | European | — | UKB | UKB Phase 1 |
Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
|
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM000054 | PSS000037 | PGP000017 Khera AV et al. (2019) |
Reported Trait: Body mass index | β: 1.41 | — | R²: 0.085264 | First 10 genetic PCs | Beta is in units of kg/m^2 |
|
PGS Sample Set ID (PSS ID) |
Detailed Phenotype Description | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000037 | — | — | 288,016 individuals, 45.0 % Male samples |
— | European | — | UKB | — |