Polygenic Score (PGS) ID: PGS000027

Predicted Trait
Reported Trait Body Mass Index
Mapped Trait(s) body mass index (EFO_0004340)
Released in PGS: Oct. 14, 2019

Score Details

Score Construction
PGS Name GPS_BMI
Variants
Original Genome Build hg19
Number of Variants 2,100,302
Development Method
Name LDpred
Parameters ρ = 0.03; LD reference panel = 503 European samples from 1000 Genomes phase 3
PGS Source
PGS Catalog Publication (PGP) ID PGP000017
Citation (link to publication) Khera AV et al. Cell (2019)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST002783
EuropePMC: 25673413
236,781 individuals European
GWAS Catalog: GCST002783
EuropePMC: 25673413
887 individuals African American or Afro-Caribbean
GWAS Catalog: GCST002783
EuropePMC: 25673413
1,276 individuals Hispanic or Latin American
Score Development/Training
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
119,951 individuals European UKB UKB Phase 1

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000054 PSS000037 PGP000017
Khera AV et al. (2019)
Reported Trait: Body mass index β: 1.41 : 0.085264 First 10 genetic PCs Beta is in units of kg/m^2

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000037 288,016 individuals,
45.0 % Male samples
European UKB