| Predicted Trait | |
| Reported Trait | Atrial fibrillation |
| Mapped Trait(s) | atrial fibrillation (EFO_0000275) |
| Score Construction | |
| PGS Name | PRS_AF |
| Variants | |
| Original Genome Build | hg19 |
| Number of Variants | 1,168 |
| Development Method | |
| Name | Pruning + Thresholding |
| Parameters | P < 10^-4; r2 < 0.5 |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000022 |
| Citation (link to publication) | Weng LC et al. Circulation (2017) |
| Study Identifiers | Sample Numbers | Sample Ancestry |
|---|---|---|
| GWAS Catalog: GCST004296 EuropePMC: 28416818 |
5,875 individuals | African American or Afro-Caribbean |
| GWAS Catalog: GCST004296 EuropePMC: 28416818 |
4,130 individuals | East Asian |
| GWAS Catalog: GCST004296 EuropePMC: 28416818 |
118,755 individuals | European |
| GWAS Catalog: GCST004296 EuropePMC: 28416818 |
3,358 individuals | Hispanic or Latin American |
| Detailed Phenotype Description | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|
| AF was defined as a reported history of AF or atrial flutter, or if an individual had undergone a cardioversion, pulmonary vein isolation procedure, atrial flutter ablation, atrioventricular node ablation, or received an ICD code of 427.3 (ICD-9) or I48 (ICD-10). | — | [ ,
47.3 % Male samples |
— | European | — | UKB | — |
Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
|
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM000079 | PSS000053 | PGP000022 Weng LC et al. (2017) |
Reported Trait: Incident atrial fibrillation | HR: 1.14[1.11, 1.16] | — | — | Clinical risk (CHARGE-AF Score: height, weight, systolic and diastolic blood pressure, current smoking status, use of antihypertensive medication, diabetes mellitus, history of myocardial infarction and heart failure), age, sex, genotyping array, 1 PC of ancestry | Unadjusted for Competing Risk of Death |
|
PGS Sample Set ID (PSS ID) |
Detailed Phenotype Description | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000053 | Participants were classified as having AF if an arrhythmia was present on an ECG obtained at a study visit or encounter with external clinicians, Holter monitoring, or noted in hospital records during a median 9.4 years of follow-up. | — | [ ,
45.9 % Male samples |
— | Other | FHS is principally composed of individuals of European ancestry | FHS | Samples were obtained from the following FHS cohorts: Original, Offspring, and Third Generation. Participants were eligible for inclusion if they were AF free at an average age of 55. |