Predicted Trait | |
Reported Trait | Atrial fibrillation |
Mapped Trait(s) | atrial fibrillation (EFO_0000275) |
Score Construction | |
PGS Name | PRS_AF |
Variants | |
Original Genome Build | hg19 |
Number of Variants | 1,168 |
Development Method | |
Name | Pruning + Thresholding |
Parameters | P < 10^-4; r2 < 0.5 |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000022 |
Citation (link to publication) | Weng LC et al. Circulation (2017) |
Study Identifiers | Sample Numbers | Sample Ancestry |
---|---|---|
GWAS Catalog: GCST004296 EuropePMC: 28416818 |
5,875 individuals | African American or Afro-Caribbean |
GWAS Catalog: GCST004296 EuropePMC: 28416818 |
4,130 individuals | East Asian |
GWAS Catalog: GCST004296 EuropePMC: 28416818 |
118,755 individuals | European |
GWAS Catalog: GCST004296 EuropePMC: 28416818 |
3,358 individuals | Hispanic or Latin American |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|
AF was defined as a reported history of AF or atrial flutter, or if an individual had undergone a cardioversion, pulmonary vein isolation procedure, atrial flutter ablation, atrioventricular node ablation, or received an ICD code of 427.3 (ICD-9) or I48 (ICD-10). | — | [ ,
47.3 % Male samples |
— | European | — | UKB | — |
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM000079 | PSS000053 | PGP000022 Weng LC et al. (2017) | Reported Trait: Incident atrial fibrillation | HR: 1.14 [1.11, 1.16] | — | — | Clinical risk (CHARGE-AF Score: height, weight, systolic and diastolic blood pressure, current smoking status, use of antihypertensive medication, diabetes mellitus, history of myocardial infarction and heart failure), age, sex, genotyping array, 1 PC of ancestry | Unadjusted for Competing Risk of Death |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000053 | Participants were classified as having AF if an arrhythmia was present on an ECG obtained at a study visit or encounter with external clinicians, Holter monitoring, or noted in hospital records during a median 9.4 years of follow-up. | — | [ ,
45.9 % Male samples |
— | European, NR | FHS is principally composed of individuals of European ancestry | FHS | Samples were obtained from the following FHS cohorts: Original, Offspring, and Third Generation. Participants were eligible for inclusion if they were AF free at an average age of 55. |