Predicted Trait | |
Reported Trait | Type 2 diabetes |
Mapped Trait(s) | type II diabetes mellitus (EFO_0001360) |
Score Construction | |
PGS Name | gePS_T2D |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 171,249 |
Development Method | |
Name | Pruning + Thresholding |
Parameters | P < 0.1; r2 < 0.6 |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000023 |
Citation (link to publication) | Mahajan A et al. Nat Genet (2018) |
Study Identifiers | Sample Numbers | Sample Ancestry |
---|---|---|
EuropePMC: 29632382 | [
|
European, African American, East Asian, Hispanic/Latino or South Asian |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|
Prevalent T2D status was defined using self-reported medical history and medication | — | [
|
— | European | — | UKB | — |
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM000080 | PSS000054 | PGP000024 Udler MS et al. (2019) Ext. | Reported Trait: Type 2 diabetes | — | AUROC: 0.66 | — | genotyping array, first 6 PCs of ancestry | — |
PPM000081 | PSS000054 | PGP000024 Udler MS et al. (2019) Ext. | Reported Trait: Type 2 diabetes | — | AUROC: 0.73 | — | age, sex, genotyping array, first 6 PCs of ancestry | — |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000054 | Prevalent T2D status was defined using self-reported medical history and medication | — | [
|
— | European | — | UKB | — |