| Predicted Trait | |
| Reported Trait | Asthma |
| Mapped Trait(s) | asthma (EFO_0000270) |
| Score Construction | |
| PGS Name | PGS_AST |
| Variants | |
| Original Genome Build | NR |
| Number of Variants | 15 |
| Development Method | |
| Name | Pruning and Thresholding (P+T) |
| Parameters | p < 5×10^-8 from meta-analysis in Moffatt 2010; R2 threshold 0.60 |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000025 |
| Citation (link to publication) | Belsky DW et al. Lancet Respir Med (2013) |
| Study Identifiers | Sample Numbers | Sample Ancestry |
|---|---|---|
| GWAS Catalog: GCST000804 EuropePMC: 20860503 |
26,475 individuals | European, Other |
Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
|
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM000082 | PSS000055 | PGP000025 Belsky DW et al. (2013) |
Reported Trait: Asthma onset, up to age 38 years | HR: 1.12[1.01, 1.26] | — | — | sex | — |
| PPM000083 | PSS000055 | PGP000025 Belsky DW et al. (2013) |
Reported Trait: Life-course-persistent asthma | RR: 1.36[1.14, 1.63] | — | — | sex | — |
| PPM000084 | PSS000056 | PGP000025 Belsky DW et al. (2013) |
Reported Trait: Asthma onset | HR: 1.17[1.01, 1.34] | AUROC: 0.61[0.53, 0.7] | — | sex | — |
| PPM000085 | PSS000056 | PGP000025 Belsky DW et al. (2013) |
Reported Trait: Life-course-persistent asthma | RR: 1.2[1.05, 1.38] | — | — | sex | — |
| PPM000086 | PSS000055 | PGP000025 Belsky DW et al. (2013) |
Reported Trait: Atopy (skin test for common allergen 2mm > control) | RR: 1.07[1.01, 1.14] | — | — | sex | — |
| PPM000087 | PSS000055 | PGP000025 Belsky DW et al. (2013) |
Reported Trait: Airway hyper-responsiveness to methacholine or albuterol | RR: 1.16[1.03, 1.32] | — | — | sex | — |
| PPM000088 | PSS000055 | PGP000025 Belsky DW et al. (2013) |
Reported Trait: Incompletely reversible airflow obstruction (IRAO, post-bronchodilator FEV1:FVC more than 2SD below mean) | RR: 1.28[1.04, 1.57] | — | — | sex | — |
| PPM000089 | PSS000055 | PGP000025 Belsky DW et al. (2013) |
Reported Trait: Admitted to hospital for asthma | RR: 1.38[1.07, 1.79] | — | — | sex | — |
|
PGS Sample Set ID (PSS ID) |
Detailed Phenotype Description | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000055 | Current asthma status was assessed at ages 9, 11, 13, 15, 18, 21, 26, 32, and 38 years from standardised interviews of study members (or their mothers if the participant was younger than 13 years) done by pulmonary specialists. Current asthma was defined as a diagnosis of asthma in addition to positive symptoms within the past 12 months, including asthma attack, recurrent wheeze (excluding study members reporting only one or two episodes lasting less than 1 h), or medical treatment for asthma. Age at asthma onset was defined as the earliest age at which wheezing symptoms or diagnosis by a physician were recorded. | Median = 38.0 years Range = [0.0, 38.0] years |
[ ,
51.0 % Male samples |
— | European | — | DMHDS | — |
| PSS000056 | Current asthma status was assessed at ages 9, 11, 13, 15, 18, 21, 26, 32, and 38 years from standardised interviews of study members (or their mothers if the participant was younger than 13 years) done by pulmonary specialists. Current asthma was defined as a diagnosis of asthma in addition to positive symptoms within the past 12 months, including asthma attack, recurrent wheeze (excluding study members reporting only one or two episodes lasting less than 1 h), or medical treatment for asthma. Age at asthma onset was defined as the earliest age at which wheezing symptoms or diagnosis by a physician were recorded. | — | 187 individuals | — | European | — | DMHDS | Subset of children from DMHDS with asthma onset in childhood (before age 13 years) |