Predicted Trait | |
Reported Trait | total cholesterol |
Mapped Trait(s) | total cholesterol measurement (EFO_0004574) |
Score Construction | |
PGS Name | GRS_TC |
Variants | |
Original Genome Build | NR |
Number of Variants | 52 |
Development Method | |
Name | Genome-wide significant SNPs |
Parameters | p < 5e-8 |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000045 |
Citation (link to publication) | Johnson L et al. PLoS One (2015) |
Study Identifiers | Sample Numbers | Sample Ancestry |
---|---|---|
GWAS Catalog: GCST000760 EuropePMC: 20686565 |
100,184 individuals | European (U.K.) |
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM000160 | PSS000097 | PGP000045 Johnson L et al. PLoS One (2015) |
Reported Trait: Serum total cholesterol (TC) levels | β: 8.57 | — | Beta (p-value): 0.583 | age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TG | Association (p-value; unadjusted for covariates) < 0.001 |
PPM000159 | PSS000098 | PGP000045 Johnson L et al. PLoS One (2015) |
Reported Trait: Serum total cholesterol (TC) levels | β: 20.69 | — | Beta (p-value): 0.0108 | age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TG | Association (p-value; unadjusted for covariates) < 0.001 |
PPM000162 | PSS000099 | PGP000045 Johnson L et al. PLoS One (2015) |
Reported Trait: Serum total cholesterol (TC) levels | β: -2.62 | — | Beta (p-value): 0.815 | age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TG | Association (p-value; unadjusted for covariates) < 0.001 |
PPM000161 | PSS000096 | PGP000045 Johnson L et al. PLoS One (2015) |
Reported Trait: Serum total cholesterol (TC) levels | β: 1.99 | — | Beta (p-value): 0.852 | age, age^2, sex, GRS_HDL, GRS_LDL, GRS_TG | Association (p-value; unadjusted for covariates) < 0.001 |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000097 | Lipid levels are represented in mg/dL, individuals on any lipid-lowering medication (n = 1,018) were omitted from all analyses. | — | 666 individuals, 50.15 % Male samples |
Mean = 61.5 years | East Asian | — | MESA | MESA Classic Cohort |
PSS000098 | Lipid levels are represented in mg/dL, individuals on any lipid-lowering medication (n = 1,018) were omitted from all analyses. | — | 2,063 individuals, 46.78 % Male samples |
Mean = 62.09 years | European | — | MESA | MESA Classic Cohort |
PSS000099 | Lipid levels are represented in mg/dL, individuals on any lipid-lowering medication (n = 1,018) were omitted from all analyses. | — | 1,256 individuals, 48.89 % Male samples |
Mean = 60.65 years | Hispanic or Latin American | — | MESA | MESA Classic Cohort |
PSS000096 | Lipid levels are represented in mg/dL, individuals on any lipid-lowering medication (n = 1,018) were omitted from all analyses. | — | 1,355 individuals, 46.2 % Male samples |
Mean = 61.68 years | African American or Afro-Caribbean | — | MESA | MESA Classic Cohort |