Predicted Trait | |
Reported Trait | Epithelial ovarian cancer |
Mapped Trait(s) | ovarian carcinoma (EFO_0001075) |
Score Construction | |
PGS Name | PRS_EOC |
Variants | |
Original Genome Build | GRCh37 |
Number of Variants | 15 |
Development Method | |
Name | Genomewide-significant SNPs |
Parameters | P < 5x10-8 in GWAS for any type of EOC |
PGS Source | |
PGS Catalog Publication (PGP) ID | PGP000048 |
Citation (link to publication) | Yang X et al. J Med Genet (2018) |
Study Identifiers | Sample Numbers | Sample Ancestry |
---|---|---|
GWAS Catalog: GCST004415 EuropePMC: 28346442 |
63,347 individuals | European |
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
---|---|---|---|---|---|---|---|---|
PPM000188 | PSS000108 | PGP000048 Yang X et al. (2018) | Reported Trait: all invasive epithelial ovarian cancer | OR: 1.32 [1.21, 1.45] | C-index: 0.58 [0.55, 0.6] | — | — | — |
PGS Sample Set ID (PSS ID) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
---|---|---|---|---|---|---|---|---|
PSS000108 | Adjudicated endpoint determined from medical notes by an outcome review committee | Mean = 11.1 years Iqr = [10.0, 12.0] years |
[ ,
0.0 % Male samples |
Mean = 63.0 years Range = [50.0, 74.0] years |
European | — | UKCTOCS | — |
PSS000108 | Adjudicated endpoint determined from medical notes by an outcome review committee | Mean = 11.1 years Iqr = [10.0, 12.0] years |
[ ,
0.0 % Male samples |
Mean = 63.0 years Range = [50.0, 74.0] years |
European | — | UKCTOCS | — |