| Predicted Trait | |
| Reported Trait | Lung cancer |
| Mapped Trait(s) | lung adenocarcinoma (EFO_0000571) |
| Score Construction | |
| PGS Name | PRS_LC_C |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 19 |
| Development Method | |
| Name | Genomewide-significant SNPs, filtered to be specific to Chinese ancestry individuals |
| Parameters | Meta-anlaysis p-value ≤5·0 × 10−8; MAF < 0.01 (in Chinese populations); r2 >= 0.1; Chinese-specific association p-value < 0.00125 |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000049 |
| Citation (link to publication) | Dai J et al. Lancet Respir Med (2019) |
| Study Identifiers | Sample Numbers | Sample Ancestry |
|---|---|---|
| GWAS Catalog: GCST008834 EuropePMC: 31326317 |
26,655 individuals | East Asian |
| GWAS Catalog: GCST008834 EuropePMC: 31326317 |
27,820 individuals | European |
Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
|
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM000190 | PSS000109 | PGP000049 Dai J et al. (2019) |
Reported Trait: Incident lung cancer | — | — | HR (High genetic risk: top 5% vs. bottom 5% of PRS): 2.37[1.64, 3.44] HR (Intermediate genetic risk: 5-95% vs. bottom 5% of PRS): 1.6[1.17, 2.2] |
age, sex, source of region, smoking status | — |
|
PGS Sample Set ID (PSS ID) |
Detailed Phenotype Description | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000109 | Participants were followed-up for cancer events mainly through linkage with official death certificates, chronic disease registries, and the Chinese national health insurance system. | Median = 10.44 years | [ ,
42.93 % Male samples |
Mean = 53.67 years Se = 10.98 years |
East Asian (Chinese) |
— | CKB | — |