PGS Catalog - PGS000117 / Cardiovascular disease (Polygenic Score)

Polygenic Score (PGS) ID: PGS000117

Predicted Trait
Reported Trait	Cardiovascular disease
Mapped Trait(s)	cardiovascular disease (EFO_0000319)

Released in PGS Catalog: March 27, 2020

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Terms and Licenses

CC0 1.0 Universal (CC0 1.0) Public Domain Dedication

Score Details

Score Construction
PGS Name	CVD_EJ2020
Development Method
Name	lassosum
Parameters	INFO score>0.999; N=1,037,385 variants; s=0.5; lambda=0.00429
Variants
Original Genome Build	GRCh37
Number of Variants	297,862
Effect Weight Type	NR

PGS Source
PGS Catalog Publication (PGP) ID	PGP000054
Citation (link to publication)	Elliott J et al. JAMA (2020)

Ancestry Distribution
Source of Variant Associations (GWAS)	European: 75.3% South Asian: 13.6% East Asian: 6% Hispanic or Latin American: 2.2% African: 1.7% Greater Middle Eastern: 1.2% 187,599 individuals (100%)
Score Development/Training	Multi-ancestry (including European): 100% European East Asian South Asian Additional Asian Ancestries Not Reported 80,103 individuals (100%)
PGS Evaluation	Multi-ancestry (including European): 83.3% European African Not Reported South Asian East Asian Additional Asian Ancestries European: 16.7% 12 Sample Sets

Development Samples

Source of Variant Associations (GWAS)

Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)
GWAS Catalog: GCST003116 Europe PMC: 26343387	4,095 individuals	Hispanic or Latin American	41 cohorts ADVANCE ,AGES ,AIDHS ,ARIC ,BAS ,BioMe ,CARDIOGENICS ,CAS ,CCGB ,COROGENE ,DUKE_2 ,EGCUT ,FGENTCARD ,FHS ,FINRISK ,FamHS ,GENRIC ,GerMIFS ,GoDARTS ,HPS ,HSDS ,HSIEA ,ITH ,LIFE-HEART ,LOLIPOP ,LURIC ,MAYO-VDB ,MIGen ,MedSTAR ,OHGS ,PIVUS ,PROCARDIS ,PROMIS ,PROSPER ,PennCATH ,RS ,SDS ,TwinGene ,ULSAM ,WGHS ,WTCCC
GWAS Catalog: GCST003116 Europe PMC: 26343387	11,323 individuals	East Asian	41 cohorts ADVANCE ,AGES ,AIDHS ,ARIC ,BAS ,BioMe ,CARDIOGENICS ,CAS ,CCGB ,COROGENE ,DUKE_2 ,EGCUT ,FGENTCARD ,FHS ,FINRISK ,FamHS ,GENRIC ,GerMIFS ,GoDARTS ,HPS ,HSDS ,HSIEA ,ITH ,LIFE-HEART ,LOLIPOP ,LURIC ,MAYO-VDB ,MIGen ,MedSTAR ,OHGS ,PIVUS ,PROCARDIS ,PROMIS ,PROSPER ,PennCATH ,RS ,SDS ,TwinGene ,ULSAM ,WGHS ,WTCCC
GWAS Catalog: GCST003116 Europe PMC: 26343387	25,557 individuals	South Asian	41 cohorts ADVANCE ,AGES ,AIDHS ,ARIC ,BAS ,BioMe ,CARDIOGENICS ,CAS ,CCGB ,COROGENE ,DUKE_2 ,EGCUT ,FGENTCARD ,FHS ,FINRISK ,FamHS ,GENRIC ,GerMIFS ,GoDARTS ,HPS ,HSDS ,HSIEA ,ITH ,LIFE-HEART ,LOLIPOP ,LURIC ,MAYO-VDB ,MIGen ,MedSTAR ,OHGS ,PIVUS ,PROCARDIS ,PROMIS ,PROSPER ,PennCATH ,RS ,SDS ,TwinGene ,ULSAM ,WGHS ,WTCCC
GWAS Catalog: GCST003116 Europe PMC: 26343387	141,217 individuals	European	41 cohorts ADVANCE ,AGES ,AIDHS ,ARIC ,BAS ,BioMe ,CARDIOGENICS ,CAS ,CCGB ,COROGENE ,DUKE_2 ,EGCUT ,FGENTCARD ,FHS ,FINRISK ,FamHS ,GENRIC ,GerMIFS ,GoDARTS ,HPS ,HSDS ,HSIEA ,ITH ,LIFE-HEART ,LOLIPOP ,LURIC ,MAYO-VDB ,MIGen ,MedSTAR ,OHGS ,PIVUS ,PROCARDIS ,PROMIS ,PROSPER ,PennCATH ,RS ,SDS ,TwinGene ,ULSAM ,WGHS ,WTCCC
GWAS Catalog: GCST003116 Europe PMC: 26343387	2,268 individuals	Greater Middle Eastern (Middle Eastern, North African or Persian)	40 cohorts ADVANCE ,AGES ,AIDHS ,ARIC ,BAS ,BioMe ,CARDIOGENICS ,CAS ,CCGB ,COROGENE ,DUKE_2 ,EGCUT ,FGENTCARD ,FHS ,FINRISK ,FamHS ,GENRIC ,GerMIFS ,GoDARTS ,HPS ,HSDS ,HSIEA ,ITH ,LIFE-HEART ,LOLIPOP ,LURIC ,MAYO-VDB ,MIGen ,MedSTAR ,OHGS ,PIVUS ,PROCARDIS ,PROMIS ,PROSPER ,PennCATH ,RS ,TwinGene ,ULSAM ,WGHS ,WTCCC
GWAS Catalog: GCST003116 Europe PMC: 26343387	3,139 individuals	African American or Afro-Caribbean	41 cohorts ADVANCE ,AGES ,AIDHS ,ARIC ,BAS ,BioMe ,CARDIOGENICS ,CAS ,CCGB ,COROGENE ,DUKE_2 ,EGCUT ,FGENTCARD ,FHS ,FINRISK ,FamHS ,GENRIC ,GerMIFS ,GoDARTS ,HPS ,HSDS ,HSIEA ,ITH ,LIFE-HEART ,LOLIPOP ,LURIC ,MAYO-VDB ,MIGen ,MedSTAR ,OHGS ,PIVUS ,PROCARDIS ,PROMIS ,PROSPER ,PennCATH ,RS ,SDS ,TwinGene ,ULSAM ,WGHS ,WTCCC

Score Development/Training

Study Identifiers	Sample Numbers	Sample Ancestry	Cohort(s)	Phenotype Definitions & Methods	Age of Study Participants	Participant Follow-up Time	Additional Ancestry Description	Additional Sample/Cohort Information
—	80,103 individuals [ 15,947 cases , 64,156 controls ] , 68.24 % Male samples	European, East Asian, South Asian, Asian unspecified, NR	UKB	Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings	Mean = 60.0 years	—	95% European, 0.2% Chinese, 1,4% Indian,0.4%Other Asian, 0.5% Pakistani, 1.1 % Other ancestries	Tuning (Case-Control) Set

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID (PPM)	PGS Sample Set ID (PSS)	Performance Source	Trait	PGS Effect Sizes (per SD change)	Classification Metrics	Other Metrics	Covariates Included in the Model	PGS Performance: Other Relevant Information
PPM000825	PSS000388\| Multi-ancestry (including European)\| 204,675 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (under age 55)	—	C-index: 0.66 [0.65, 0.66]	—	age,sex	—
PPM000826	PSS000388\| Multi-ancestry (including European)\| 204,675 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (under age 55)	—	C-index: 0.7 [0.7, 0.71]	—	pooled cohort equations	—
PPM000828	PSS000384\| Multi-ancestry (including European)\| 147,985 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (over age 55)	—	C-index: 0.7 [0.69, 0.71]	—	age,sex	—
PPM000829	PSS000384\| Multi-ancestry (including European)\| 147,985 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (over age 55)	—	C-index: 0.77 [0.76, 0.78]	—	pooled cohort equations	—
PPM000831	PSS000392\| Multi-ancestry (including European)\| 147,363 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (in males)	—	C-index: 0.67 [0.66, 0.67]	—	age,sex	—
PPM000832	PSS000392\| Multi-ancestry (including European)\| 147,363 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (in males)	—	C-index: 0.71 [0.71, 0.72]	—	pooled cohort equations	—
PPM000834	PSS000396\| Multi-ancestry (including European)\| 205,297 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (in females)	—	C-index: 0.69 [0.68, 0.7]	—	age,sex	—
PPM000835	PSS000396\| Multi-ancestry (including European)\| 205,297 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (in females)	—	C-index: 0.74 [0.73, 0.75]	—	pooled cohort equations	—
PPM000823	PSS000400\| Multi-ancestry (including European)\| 352,660 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease	—	C-index: 0.75 [0.75, 0.76]	—	pooled cohort equations	—
PPM000841	PSS000402\| Multi-ancestry (including European)\| 350,730 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease	—	C-index: 0.75 [0.75, 0.76]	—	QRISK3	—
PPM000842	PSS000390\| Multi-ancestry (including European)\| 203,620 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (over age 55)	—	C-index: 0.7 [0.7, 0.71]	—	QRISK3	—
PPM000843	PSS000386\| Multi-ancestry (including European)\| 147,110 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (under age 55)	—	C-index: 0.77 [0.76, 0.78]	—	QRISK3	—
PPM000844	PSS000394\| Multi-ancestry (including European)\| 146,573 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (in males)	—	C-index: 0.71 [0.71, 0.72]	—	QRISK3	—
PPM000845	PSS000398\| Multi-ancestry (including European)\| 204,157 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (in females)	—	C-index: 0.74 [0.73, 0.75]	—	QRISK3	—
PPM000822	PSS000400\| Multi-ancestry (including European)\| 352,660 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease	—	C-index: 0.71 [0.71, 0.72]	—	age,sex	—
PPM000824	PSS000388\| Multi-ancestry (including European)\| 204,675 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (under age 55)	—	C-index: 0.56 [0.55, 0.56]	—	—	—
PPM000827	PSS000384\| Multi-ancestry (including European)\| 147,985 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (over age 55)	—	C-index: 0.59 [0.58, 0.61]	—	—	—
PPM000830	PSS000392\| Multi-ancestry (including European)\| 147,363 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (in males)	—	C-index: 0.57 [0.56, 0.57]	—	—	—
PPM000833	PSS000396\| Multi-ancestry (including European)\| 205,297 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease (in females)	—	C-index: 0.56 [0.55, 0.57]	—	—	—
PPM000821	PSS000400\| Multi-ancestry (including European)\| 352,660 individuals	PGP000054 \| Elliott J et al. JAMA (2020)	Reported Trait: Incident cardiovascular disease	—	C-index: 0.56 [0.56, 0.57]	—	—	—
PPM017096	PSS010120\| European Ancestry\| 4,218 individuals	PGP000433 \| de La Harpe R et al. Eur J Prev Cardiol (2023) \|Ext.	Reported Trait: Atherosclerotic cardiovascular disease (incident and prevalent)	OR: 1.36 [1.21, 1.52]	AUROC: 0.768 [0.743, 0.794]	—	sex, age	—
PPM017097	PSS010119\| European Ancestry\| 3,383 individuals	PGP000433 \| de La Harpe R et al. Eur J Prev Cardiol (2023) \|Ext.	Reported Trait: Incident atherosclerotic cardiovascular disease	HR: 1.3 [1.13, 1.5]	—	—	sex, age, 10 principal components	—

Evaluated Samples

PGS Sample Set ID (PSS)	Phenotype Definitions and Methods	Participant Follow-up Time	Sample Numbers	Age of Study Participants	Sample Ancestry	Additional Ancestry Description	Cohort(s)	Additional Sample/Cohort Information
PSS010119	Atherosclerotic cardiovacular disease (ASCVD), comprising non-fatal acute myocardial infarction, death of cardiovascular origin (comprising sudden death, ischemic death) and fatal and non-fatal ischaemic stroke (including transient ischaemic attack) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036	Median = [10.7, 14.6] years	3,383 individuals [ 190 cases , 3,193 controls ] , 45.0 % Male samples	Mean = 52.3 years	European	—	CoLaus	right censored was death or latest evidence of good health, participant with statine therapy at baseline were excluded
PSS010120	Atherosclerotic cardiovacular disease (ASCVD), comprising non-fatal acute myocardial infarction, death of cardiovascular origin (comprising sudden death, ischemic death) and fatal and non-fatal ischaemic stroke (including transient ischaemic attack) using relevant medical records and ICD codes. All events were adjudicated by two expert. More details in PMID: 33838036	Median = [10.6, 14.6] years	4,218 individuals [ 363 cases , 3,855 controls ] , 47.0 % Male samples	Mean = 53.4 years	European	—	CoLaus	right censored was death or latest evidence of good health
PSS000384	Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	147,985 individuals [ 10,899 cases , 137,086 controls ]	Range = [40.0, 55.0] years	European, African unspecified, NR	98.3% White European, 1.7% Black/Other	UKB	PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000386	Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	147,110 individuals [ 2,826 cases , 144,284 controls ]	Range = [40.0, 55.0] years	European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified	2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry	UKB	QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000388	Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	204,675 individuals [ 2,854 cases , 201,821 controls ]	Range = [55.0, 69.0] years	European, African unspecified, NR	98.3% White European, 1.7% Black/Other	UKB	PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000390	Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	203,620 individuals [ 10,824 cases , 192,796 controls ]	Range = [55.0, 69.0] years	European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified	2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry	UKB	QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000392	Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	147,363 individuals [ 8,595 cases , 138,768 controls ] , 100.0 % Male samples	Mean = 55.79 years Sd = 8.35 years	European, African unspecified, NR	98.3% White European, 1.7% Black/Other	UKB	PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000394	Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	146,573 individuals [ 8,536 cases , 138,037 controls ] , 100.0 % Male samples	Mean = 55.8 years Sd = 8.3 years	European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified	2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry	UKB	QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000396	Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	205,297 individuals [ 5,158 cases , 200,139 controls ] , 0.0 % Male samples	Mean = 56.0 years Sd = 8.01 years	European, African unspecified, NR	98.3% White European, 1.7% Black/Other	UKB	PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000398	Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	204,157 individuals [ 5,114 cases , 199,043 controls ] , 0.0 % Male samples	Mean = 56.0 years Sd = 8.0 years	European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified	2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry	UKB	QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)
PSS000400	Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	352,660 individuals [ 13,753 cases , 338,907 controls ] , 41.8 % Male samples	Mean = 55.9 years Range = [40.0, 69.0] years	European, African unspecified, NR	98.3% White European, 1.7% Black/Other	UKB	PCE Prospective Cohort (lipid-lowering treatment performed)
PSS000402	Cardiovascular disease was defined as coronary artery disease, and additionally includes angina, nonhemorrhagic stroke, and transient ischemic attack. ICD-10 codes: G45, I20, I21, I22, I23, I24.1, I25, I63. I64 ICD-9 codes: 410, 411, 412, 413, 414, 434, 436 OPCS-4 codes: K40, K41, K42, K43, K44, K45, K46, K47.1, K49, K50, K75 UKBiobank field 20002 codes: 1074, 1075, 1082, 1548 UKBiobank field 20004 codes: 1070, 1071, 1095, 1105, 1109, 1514 UKBiobank field 6150 codes: 1, 2, 3 See eTable 1 for risk factor codings	Mean = 8.01 years Sd = 1.04 years	350,730 individuals [ 13,650 cases , 337,080 controls ] , 41.0 % Male samples	Range = [40.0, 69.0] years	European, South Asian, African American or Afro-Caribbean, African unspecified, East Asian, Asian unspecified	2,332 Africans, 145 Bangladeshi, 3,165 Carribeans, 1,136 Chinese, 3,790 Indians, 1,258 Other Asians, 1,182 Pakistani, 332,326 White Europeans and Unkown ancestry	UKB	QRISK3 Prospective Cohort/Testing Set (lipid-lowering treatment performed)