Polygenic Score (PGS) ID: PGS000123

Predicted Trait
Reported Trait Parkinson disease
Mapped Trait(s) Parkinson's disease (EFO_0002508)
Released in PGS: March 27, 2020

Score Details

Score Construction
PGS Name 2017_PD16
Variants
Original Genome Build NR
Number of Variants 16
Development Method
Name GWAS significant SNPs
Parameters The PRS was computed using the binary logarithm transformation of the reported ORs
PGS Source
PGS Catalog Publication (PGP) ID PGP000059
Citation (link to publication) Ibanez L et al. BMC Neurol (2017)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST002544
EuropePMC: 25064009
108,990 individuals European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000395 PSS000225 PGP000059
Ibanez L et al. (2017)
Reported Trait: Parkinson disease β: 5.84[3.1, 8.59] Association (p-value): 3.45e-05 age at last assessment, sex, 2 PCs of ancestry
PPM000397 PSS000226 PGP000059
Ibanez L et al. (2017)
Reported Trait: Parkinson disease β: 4.85[2.32, 7.39] Association (p-value): 0.000182 age at last assessment, sex, 2 PCs of ancestry
PPM000396 PSS000225 PGP000059
Ibanez L et al. (2017)
Reported Trait: Age at Onset (Survival) β: 16.62[9.63, 23.61] Association (p-value): 3.19e-06 age at last assessment, sex, 2 PCs of ancestry Cox regression
PPM000398 PSS000226 PGP000059
Ibanez L et al. (2017)
Reported Trait: Age at Onset (Survival) β: 9.3[3.59, 15.0] Association (p-value): 0.00141 age at last assessment, sex, 2 PCs of ancestry Cox regression

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000226
[
  • 493 cases
  • , 293 controls
]
,
58.27 % Male samples
European WUSTL Both the PPMI and WUSTL datasets are available by request from the PPMI website (www.ppmi-info.org)
PSS000225
[
  • 334 cases
  • , 135 controls
]
,
55.22 % Male samples
European PPMI Both the PPMI and WUSTL datasets are available by request from the PPMI website (www.ppmi-info.org)