| Predicted Trait | |
| Reported Trait | Type 2 diabetes (T2D) |
| Mapped Trait(s) | type 2 diabetes mellitus (MONDO_0005148) |
| Score Construction | |
| PGS Name | Qi_T2D_2017 |
| Development Method | |
| Name | Genome-wide significant variants |
| Parameters | Unweighted allele count |
| Variants | |
| Original Genome Build | NR |
| Number of Variants | 80 |
| Effect Weight Type | Dosage |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000062 |
| Citation (link to publication) | Qi Q et al. Diabetes (2017) |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST002317 Europe PMC: 24390345 |
8,214 individuals | Hispanic or Latin American | NR |
GWAS Catalog: GCST002560 Europe PMC: 2510218 |
23,827 individuals | African American or Afro-Caribbean | NR |
GWAS Catalog: GCST002352 Europe PMC: 2450948 |
2,583 individuals | Hispanic or Latin American | NR |
GWAS Catalog: GCST002352 Europe PMC: 2450948 |
20,019 individuals | South Asian | NR |
GWAS Catalog: GCST002352 Europe PMC: 2450948 |
69,033 individuals | European | NR |
GWAS Catalog: GCST002352 Europe PMC: 2450948 |
18,817 individuals | East Asian | NR |
GWAS Catalog: GCST002128 Europe PMC: 23945395 |
26,805 individuals | East Asian | NR |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM000404 | PSS000232| Hispanic or Latin American Ancestry| 7,746 individuals |
PGP000062 | Qi Q et al. Diabetes (2017) |
Reported Trait: Type 2 Diabetes | — | — | OR (Odds Ratio, per risk allele): 1.07 [1.06, 1.08] | center, age, sex, 5 PCs of ancestry | Covariance matrices corresponding to genetic relatedness (kinship), household, and census block group were included as random effects in the mixed model analysis |
| PPM022775 | PSS012080| Greater Middle Eastern Ancestry| 4,534 individuals |
PGP000753 | Aliyu U et al. Diabetes Obes Metab (2025) |Ext. |
Reported Trait: Prediabetes | OR: 1.17 [1.1, 1.245] | AUROC: 0.646 [0.631, 0.662] | R²: 0.082 | sex, baseline age, BMI, PCs1-10 | — |
| PPM022945 | PSS012081| Greater Middle Eastern Ancestry| 2,143 individuals |
PGP000753 | Aliyu U et al. Diabetes Obes Metab (2025) |Ext. |
Reported Trait: Incident T2D in prediabetics | HR: 1.411 [1.22, 1.632] | AUROC: 0.761 [0.728, 0.794] | — | sex, baseline age, BMI, PCs1-10 | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS012080 | age-matched cohort | — | [
|
— | Greater Middle Eastern (Middle Eastern, North African or Persian) (Qatari) |
— | QBB | — |
| PSS012081 | — | Median = 6.0 years | [ ,
54.22 % Male samples |
— | Greater Middle Eastern (Middle Eastern, North African or Persian) (Qatari) |
— | QBB | — |
| PSS000232 | Individuals with T2D were defined as those with fasting time >8 h and fasting glucose levels ≥126 mg/dL, fasting ≤8 h and fasting glucose ≥200 mg/dL, post–oral glucose tolerance test glucose ≥200 mg/dL, HbA1c ≥6.5% (48 mmol/mol), or on current treatment with antihyperglycemia medications. | — | [ ,
39.65 % Male samples |
— | Hispanic or Latin American (Central American, Cuban, Dominican, Mexican, Puerto Rican, South American) |
Ancestry groups were defined based on a combination of self-identified Hispanic/Latino background and genetic similarity | HCHS, SOL | — |