| Predicted Trait | |
| Reported Trait | Type 2 Diabetes |
| Mapped Trait(s) | type II diabetes mellitus (EFO_0001360) |
| Score Construction | |
| PGS Name | Qi_T2D_2017 |
| Variants | |
| Original Genome Build | NR |
| Number of Variants | 80 |
| Development Method | |
| Name | GWAS-significant SNPs |
| Parameters | Unweighted allele count |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000062 |
| Citation (link to publication) | Qi Q et al. Diabetes (2017) |
| Study Identifiers | Sample Numbers | Sample Ancestry |
|---|---|---|
| GWAS Catalog: GCST002317 EuropePMC: 24390345 |
8,214 individuals | Hispanic or Latin American |
| GWAS Catalog: GCST002560 EuropePMC: 2510218 |
23,827 individuals | African American or Afro-Caribbean |
| GWAS Catalog: GCST002352 EuropePMC: 2450948 |
2,583 individuals | Hispanic or Latin American |
| GWAS Catalog: GCST002352 EuropePMC: 2450948 |
20,019 individuals | South Asian |
| GWAS Catalog: GCST002352 EuropePMC: 2450948 |
69,033 individuals | European |
| GWAS Catalog: GCST002352 EuropePMC: 2450948 |
18,817 individuals | East Asian |
| GWAS Catalog: GCST002128 EuropePMC: 23945395 |
26,805 individuals | East Asian |
Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.
|
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM000404 | PSS000232 | PGP000062 Qi Q et al. (2017) |
Reported Trait: Type 2 Diabetes | — | — | OR (Odds Ratio, per risk allele): 1.07[1.06, 1.08] | center, age, sex, 5 PCs of ancestry | Covariance matrices corresponding to genetic relatedness (kinship), household, and census block group were included as random effects in the mixed model analysis |
|
PGS Sample Set ID (PSS ID) |
Detailed Phenotype Description | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000232 | Individuals with T2D were defined as those with fasting time >8 h and fasting glucose levels ≥126 mg/dL, fasting ≤8 h and fasting glucose ≥200 mg/dL, post–oral glucose tolerance test glucose ≥200 mg/dL, HbA1c ≥6.5% (48 mmol/mol), or on current treatment with antihyperglycemia medications. | — | [ ,
39.65 % Male samples |
— | Hispanic or Latin American (Central American, Cuban, Dominican, Mexican, Puerto Rican, South American) |
Ancestry groups were defined based on a combination of self-identified Hispanic/Latino background and genetic similarity | HCHS, SOL | — |