Polygenic Score (PGS) ID: PGS000126

Predicted Trait
Reported Trait Serum urate
Mapped Trait(s) urate measurement (EFO_0004531)
Released in PGS: March 27, 2020

Score Details

Score Construction
PGS Name Urate_GRS
Variants
Original Genome Build GRCh37
Number of Variants 114
Development Method
Name GWAS-significant SNPs
Parameters Conditionally independent GWAS loci in Europeans
PGS Source
PGS Catalog Publication (PGP) ID PGP000063
Citation (link to publication) Tin A et al. Nat Genet (2019)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST008971
EuropePMC: 31578528
288,649 individuals European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000405 PSS000233 PGP000063
Tin A et al. (2019)
Reported Trait: Prevalent gout cases AUROC: 0.67
PPM000406 PSS000233 PGP000063
Tin A et al. (2019)
Reported Trait: Prevalent gout cases AUROC: 0.84 age, sex

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000233 Gout identified by self-report at the inclusion visit, individuals with an ICD-10 for gout (M10) in hospital admissions who did not self-report gout were excluded from the analysis.
[
  • 4,908 cases
  • , 329,972 controls
]
European White British subset, unrelated UKB