Polygenic Score (PGS) ID: PGS000132

Predicted Trait
Reported Trait Hemoglobin A1c
Mapped Trait(s) HbA1c measurement (EFO_0004541)
Additional Trait Information Score composed of glycemic variants associated with HbA1c, used to predict diabetes incidence
Released in PGS: March 27, 2020

Score Details

Score Construction
Original Genome Build GRCh36
Number of Variants 19
Development Method
Parameters Study-wide multi-ancestry GWAS significant SNPs
PGS Source
PGS Catalog Publication (PGP) ID PGP000064
Citation (link to publication) Wheeler E et al. PLoS Med (2017)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST007953
EuropePMC: 28898252
18,472 individuals East Asian

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000412 PSS000235 PGP000064
Wheeler E et al. (2017)
Reported Trait: Incident type 2 diabetes OR: 1.05[1.02, 1.07] age, sex

Evaluated Samples

PGS Sample Set ID
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000235 Incident type 2 diabtes defined as fasting glucose >= 7 mmol/L, 2 hour glucose >= 11.1 mmol/L, antidiabetic medication use, or a physician diagnosis of type 2 diabetes Range = [10.0, 15.0] years
  • 2,391 cases
  • , 2,682 controls
0.47 % Male samples
Mean = 55.6 years
Sd = 7.37 years
East Asian MESA, SCHS Partial overlap with discovery GWAS