| Predicted Trait | |
| Reported Trait | Cholesterol |
| Mapped Trait(s) | |
| Score Construction | |
| PGS Name | GS9 |
| Variants | |
| Original Genome Build | NCBI35 |
| Number of Variants | 9 |
| Development Method | |
| Name | Curated variant associations |
| Parameters | Correlated SNPs were pruned from the score |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000079 |
| Citation (link to publication) | Kathiresan S et al. N Engl J Med (2008) |
| Study Identifiers | Sample Numbers | Sample Ancestry |
|---|---|---|
| EuropePMC: 10.1210/jc.2005-0974 | 9,185 individuals | European |
| EuropePMC: 10.1086/500615 | 1,822 individuals | African American or Afro-Caribbean |
| EuropePMC: 10.1086/500615 | 1,045 individuals | European |
| EuropePMC: 10.1086/500615 | 601 individuals | Hispanic or Latin American |
| EuropePMC: 10.1161/01.CIR.0000153341.46271.4 | 13,677 individuals | Other |
| EuropePMC: 10.1073/pnas.94.9.4532 | 1,465 individuals | European |
| 3,000 individuals | European |
|
PGS Performance Metric ID (PPM ID) |
PGS Sample Set ID (PSS ID) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
PGS Classification Metrics | Other Metrics | Covariates Included in the Model | PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM000561 | PSS000292 | PGP000079 Kathiresan S et al. (2008) |
Reported Trait: Low-density lipoprotein (LDL) levels | — | — | Association p-value: 3e-24 | — | — |
| PPM000562 | PSS000292 | PGP000079 Kathiresan S et al. (2008) |
Reported Trait: High-density lipoprotein (HDL) levels | — | — | Association p-value: 2e-18 | — | — |
| PPM000563 | PSS000292 | PGP000079 Kathiresan S et al. (2008) |
Reported Trait: Incident cardiovascular event | — | AUROC: 0.8 | Hazard Ratio (HR; per allele): 1.15[1.07, 1.24] | age, sex, family history of MI, LDL cholesterol, HDL cholesterol, triglycerides, blood pressure, body mass index, diabetes status, smoking status, CRP, lipid lowering medication | — |
|
PGS Sample Set ID (PSS ID) |
Detailed Phenotype Description | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000292 | Composite end point of cardiovascular events was defined as myocardial infarction, ischemic stroke, and death from coronary heart disease. Death from coronary heart disease was defined on the basis of codes 412 and 414 (ICD-9) or I22–I23 and I25 (ICD-10) in the Swedish Cause of Death Register. Myocardial infarction was defined on the basis of codes 410 and I21 in the International Classification of Diseases, 9th Revision and 10th Revision (ICD-9 and ICD-10), respectively. Ischemic stroke was defined on the basis of codes 434 or 436 (ICD-9) and I63 or I64 (ICD-10). | Median = 10.6 years | [
|
— | European | — | MDC | — |