Polygenic Score (PGS) ID: PGS000203

Predicted Trait
Reported Trait Alcohol consumption (drinks per week)
Mapped Trait(s) alcohol consumption measurement (EFO_0007878)
Released in PGS Catalog: July 1, 2020
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Score Details

Score Construction
PGS Name GSCAN_DPW_COGA
Development Method
Name PRS-CS
Parameters LD-reference panel = 1000G Europeans; SNPs selected to overlap HapMap3 and COGA
Variants
Original Genome Build NR
Number of Variants 1,110,910
Effect Weight Type NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000084
Citation (link to publication) Barr PB et al. Transl Psychiatry (2020)
Ancestry Distribution
Source of Variant
Associations (GWAS)
European: 100%
534,683 individuals (100%)
PGS Evaluation
European: 100%
1 Sample Sets

Development Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry Cohort(s)
Europe PMC: 30643251
 534,683 individuals European NR

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance
Metric ID (PPM) 		PGS Sample Set ID
(PSS) 		Performance Source Trait PGS Effect Sizes
(per SD change) 		Classification Metrics Other Metrics Covariates Included in the Model PGS Performance:
Other Relevant Information
PPM000625 PSS000339|
European Ancestry|
7,599 individuals
 PGP000084 |
Barr PB et al. Transl Psychiatry (2020)
 Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.121 (0.01) — ΔR-squared (vs. covariates alone): 0.01734 sex, age of last observation, 10 Genetic PCs, genotyping array, data collection site —

Evaluated Samples

PGS Sample Set ID
(PSS) 		Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000339 — — 7,599 individuals,
47.16 % Male samples
 Mean = 36.94 years
Sd = 14.77 years
Range = [12.0, 91.0] years		 European — COGA —