Polygenic Score (PGS) ID: PGS000205

Predicted Trait
Reported Trait Risk-taking tendency (4-domain principal component model)
Mapped Trait(s) risk-taking behaviour (EFO_0008579)
Released in PGS: July 1, 2020

Score Details

Score Construction
PGS Name RISK_PC_COGA
Variants
Original Genome Build NR
Number of Variants 1,110,737
Development Method
Name PRS-CS
Parameters LD-reference panel = 1000G Europeans; SNPs selected to overlap HapMap3 and COGA
PGS Source
PGS Catalog Publication (PGP) ID PGP000084
Citation (link to publication) Barr PB et al. Transl Psychiatry (2020)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST007323
EuropePMC: 30643258
315,894 individuals European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000627 PSS000339 PGP000084
Barr PB et al. (2020)
Reported Trait: Alcohol use disorder (DSM-5 criteria count, log-transformed) β: 0.117 ΔR-squared (vs. covariates alone): 0.01613 sex, age of last observation, 10 Genetic PCs, genotyping array, data collection site

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000339 7,599 individuals,
47.16 % Male samples
Mean = 36.94 years
Sd = 14.77 years
Range = [12.0, 91.0] years
European COGA