Polygenic Score (PGS) ID: PGS000209

Predicted Trait
Reported Trait Thyroid cancer
Mapped Trait(s) thyroid carcinoma (EFO_0002892)
Released in PGS: July 1, 2020

Score Details

Score Construction
Original Genome Build GRCh38
Number of Variants 10
Development Method
Name Genomewide-significant SNPs
Parameters NR
PGS Source
PGS Catalog Publication (PGP) ID PGP000085
Citation (link to publication) Liyanarachchi S et al. Proc Natl Acad Sci U S A (2020)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
  • 3,001 cases
  • , 287,550 controls

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
PGS Sample Set ID
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000633 PSS000343 PGP000085
Liyanarachchi S et al. (2020)
Reported Trait: Thyroid cancer AUROC: 0.694[0.673, 0.716] gender, birth year AUROC (Clinical factors alone) = 0.629 [0.606 - 0.651]

Evaluated Samples

PGS Sample Set ID
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000343 Cases were ascertained using ICD-10 C73 (PTC, FTC, cancer/carcinoma, and rare nonmedullary)
  • 534 cases
  • , 407,945 controls
45.97 % Male samples
European UKB