Polygenic Score (PGS) ID: PGS000210

Predicted Trait
Reported Trait Lung function (FEV1/FVC)
Mapped Trait(s) FEV/FEC ratio (EFO_0004713)
Released in PGS: July 1, 2020

Score Details

Score Construction
PGS Name LF279
Variants
Original Genome Build GRCh37
Number of Variants 279
Development Method
Name GWAS significant variants
Parameters Sentinel variants
PGS Source
PGS Catalog Publication (PGP) ID PGP000086
Citation (link to publication) Shrine N et al. Nat Genet (2019)

Contributing Samples

Source of Variant Associations (GWAS)
Study Identifiers Sample Numbers Sample Ancestry
GWAS Catalog: GCST007431
EuropePMC: 30804560
321,047 individuals European

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000643 PSS000353 PGP000086
Shrine N et al. (2019)
Reported Trait: Lung Function (FEV1/FVC) β: -0.176[-0.231, -0.12] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000641 PSS000354 PGP000086
Shrine N et al. (2019)
Reported Trait: Lung Function (FEV1/FVC) β: -0.142[-0.191, -0.093] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000640 PSS000357 PGP000086
Shrine N et al. (2019)
Reported Trait: Lung Function (FEV1/FVC) β: -0.181[-0.205, -0.156] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000639 PSS000352 PGP000086
Shrine N et al. (2019)
Reported Trait: Lung Function (FEV1/FVC) β: -0.086[-0.116, -0.056] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000638 PSS000345 PGP000086
Shrine N et al. (2019)
Reported Trait: Chronic obstructive pulmonary disease OR: 1.219[1.182, 1.256] age, age^2, sex, height, smoking Models were stratified by geographical region and meta-analyzed. 12 Proxy SNPs were used
PPM000637 PSS000349 PGP000086
Shrine N et al. (2019)
Reported Trait: Chronic obstructive pulmonary disease OR: 1.506[1.325, 1.712] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000636 PSS000348 PGP000086
Shrine N et al. (2019)
Reported Trait: Chronic obstructive pulmonary disease OR: 1.436[1.411, 1.461] age, age^2, sex, height, smoking, 10 genetic PCs *Potential inflation (some weights are derived in a UKB GWAS)
PPM000635 PSS000350 PGP000086
Shrine N et al. (2019)
Reported Trait: Chronic obstructive pulmonary disease OR: 1.414[1.254, 1.594] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000634 PSS000347 PGP000086
Shrine N et al. (2019)
Reported Trait: Chronic obstructive pulmonary disease OR: 1.348[1.152, 1.577] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000646 PSS000344 PGP000086
Shrine N et al. (2019)
Reported Trait: Chronic obstructive pulmonary disease OR: 1.255[1.147, 1.374] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000645 PSS000351 PGP000086
Shrine N et al. (2019)
Reported Trait: Lung Function (FEV1/FVC) β: -0.078[-0.085, -0.071] age, age^2, sex, height, smoking Models were stratified by geographical region and meta-analyzed. 12 Proxy SNPs were used
PPM000647 PSS000346 PGP000086
Shrine N et al. (2019)
Reported Trait: Chronic obstructive pulmonary disease OR: 1.546[1.476, 1.62] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000644 PSS000356 PGP000086
Shrine N et al. (2019)
Reported Trait: Lung Function (FEV1/FVC) β: -0.186[-0.211, -0.162] age, age^2, sex, height, smoking, 10 genetic PCs
PPM000642 PSS000355 PGP000086
Shrine N et al. (2019)
Reported Trait: Lung Function (FEV1/FVC) β: -0.224[-0.227, -0.221] age, age^2, sex, height, smoking, 10 genetic PCs *Potential inflation (some weights are derived in a UKB GWAS)

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Detailed Phenotype Description Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000352 4,225 individuals African unspecified UKB
PSS000353 1,208 individuals Other admixed ancestry
(Admixed African (unspecified) and European)
UKB
PSS000354 1,607 individuals East Asian UKB
PSS000355 303,570 individuals European UKB
PSS000356 6,033 individuals Other admixed ancestry UKB
PSS000357 6,358 individuals South Asian UKB
PSS000344
[
  • 910 cases
  • , 1,556 controls
]
African American or Afro-Caribbean COPDGene
PSS000345 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards)
[
  • 69,567 cases
  • , 6,013 controls
]
East Asian
(Chinese)
CKB
PSS000346
[
  • 6,979 cases
  • , 3,915 controls
]
European 6 cohorts
  • COPDGene
  • ,ECLIPSE
  • ,GenKOLS
  • ,NAS
  • ,NETT
  • ,SPIROMICS
PSS000347 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards)
[
  • 172 cases
  • , 4,053 controls
]
African unspecified UKB
PSS000348 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards)
[
  • 288,467 cases
  • , 15,103 controls
]
European UKB
PSS000349 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards)
[
  • 5,752 cases
  • , 281 controls
]
Other admixed ancestry UKB
PSS000350 FEV1/FVC<0.7 and FEV1<80% predicted (i.e. corresponding to GOLD 2-4 standards)
[
  • 6,046 cases
  • , 312 controls
]
South Asian UKB
PSS000351 72,796 individuals East Asian
(Chinese)
CKB