Polygenic Score (PGS) ID: PGS000321

Predicted Trait
Reported Trait Serum testosterone levels
Mapped Trait(s) testosterone measurement (EFO_0004908)
Released in PGS: Sept. 4, 2020

Score Details

Score Construction
PGS Name snpnet_Testosterone_combined
Variants
Original Genome Build GRCh37
Number of Variants 7,319
Development Method
Name snpnet
Parameters Lasso-penalized regression (BASIL) of LD-pruned variants (plink '--indep 50 5 2') outside MHC region (chr6:25477797-36448354); MAF > 1%
PGS Source
PGS Catalog Publication (PGP) ID PGP000097
Citation (link to publication) Flynn E et al. Eur J Hum Genet (2020)

Contributing Samples

Score Development/Training
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
Blood testosterone levels (UKB field 30850). Individuals taking the following testosterone-related drugs (methyltestosterone, finasteride, dutasteride, testosterone, mesterolone, and cyproterone) were excluded. 200,477 individuals,
50.34 % Male samples
European UKB Training
Blood testosterone levels (UKB field 30850). Individuals taking the following testosterone-related drugs (methyltestosterone, finasteride, dutasteride, testosterone, mesterolone, and cyproterone) were excluded. 28,643 individuals,
50.95 % Male samples
European UKB Validation (used to select the optimal lambda value for sparsity)

Performance Metrics

Disclaimer: The performance metrics are displayed as reported by the source studies. It is important to note that metrics are not necessarily comparable with each other. For example, metrics depend on the sample characteristics (described by the PGS Catalog Sample Set [PSS] ID), phenotyping, and statistical modelling. Please refer to the source publication for additional guidance on performance.

PGS Performance Metric ID
(PPM ID)
PGS Sample Set ID
(PSS ID)
Performance Source Trait PGS Effect Sizes
(per SD change)
PGS Classification Metrics Other Metrics Covariates Included in the Model PGS Performance: Other Relevant Information
PPM000862 PSS000422 PGP000097
Flynn E et al. (2020)
Reported Trait: Serum testosterone levels in males : 0.21 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array
PPM000865 PSS000421 PGP000097
Flynn E et al. (2020)
Reported Trait: Serum testosterone levels in females : 0.13 age, sex, PCs 1-40, blood draw time, fasting time, sample dilution factor, batch, genotyping array

Evaluated Samples

PGS Sample Set ID
(PSS ID)
Phenotype Definitions and Methods Participant Follow-up Time Sample Numbers Age of Study Participants Sample Ancestry Additional Ancestry Description Cohort(s) Additional Sample/Cohort Information
PSS000421 Blood testosterone levels (UKB field 30850). Individuals taking the following testosterone-related drugs (methyltestosterone, finasteride, dutasteride, testosterone, mesterolone, and cyproterone) were excluded. 28,640 individuals,
0.0 % Male samples
European UKB
PSS000422 Blood testosterone levels (UKB field 30850). Individuals taking the following testosterone-related drugs (methyltestosterone, finasteride, dutasteride, testosterone, mesterolone, and cyproterone) were excluded. 28,601 individuals,
100.0 % Male samples
European UKB