| Predicted Trait | |
| Reported Trait | Chronotype |
| Mapped Trait(s) | chronotype measurement (EFO_0008328) |
| Score Construction | |
| PGS Name | GRS313_Chron |
| Development Method | |
| Name | Genome-wide significant variants |
| Parameters | NR |
| Variants | |
| Original Genome Build | GRCh37 |
| Number of Variants | 313 |
| Effect Weight Type | ln(OR) |
| PGS Source | |
| PGS Catalog Publication (PGP) ID | PGP000103 |
| Citation (link to publication) | Maukonen M et al. J Biol Rhythms (2020) |
| Ancestry Distribution | |
| Source of Variant Associations (GWAS) | European: 100% 403,195 individuals (100%) |
| PGS Evaluation | European: 100% 3 Sample Sets |
| Study Identifiers | Sample Numbers | Sample Ancestry | Cohort(s) |
|---|---|---|---|
GWAS Catalog: GCST007565 Europe PMC: 30696823 |
403,195 individuals | European | 23andMe, UKB |
|
PGS Performance Metric ID (PPM) |
PGS Sample Set ID (PSS) |
Performance Source | Trait |
PGS Effect Sizes (per SD change) |
Classification Metrics | Other Metrics | Covariates Included in the Model |
PGS Performance: Other Relevant Information |
|---|---|---|---|---|---|---|---|---|
| PPM000905 | PSS000452| European Ancestry| 7,436 individuals |
PGP000103 | Maukonen M et al. J Biol Rhythms (2020) |
Reported Trait: Later (evening) chronotype | OR: 1.24 [1.18, 1.31] | — | R²: 0.01312 | Age, sex, PCs (1-5), genotyping batch | — |
| PPM000904 | PSS000453| European Ancestry| 7,436 individuals |
PGP000103 | Maukonen M et al. J Biol Rhythms (2020) |
Reported Trait: Later (evening) chronotype | β: -0.49 (0.05) | — | R²: 0.01378 | Age, sex, PCs (1-5), genotyping batch | — |
| PPM000906 | PSS000451| European Ancestry| 8,433 individuals |
PGP000103 | Maukonen M et al. J Biol Rhythms (2020) |
Reported Trait: Later (evening) chronotype | OR: 1.3 [1.24, 1.37] | — | R²: 0.01893 | Age, sex, PCs (1-5), genotyping batch | — |
|
PGS Sample Set ID (PSS) |
Phenotype Definitions and Methods | Participant Follow-up Time | Sample Numbers | Age of Study Participants | Sample Ancestry | Additional Ancestry Description | Cohort(s) | Additional Sample/Cohort Information |
|---|---|---|---|---|---|---|---|---|
| PSS000451 | Chronotype was assessed using a singl self-evaluatation question from a shortend version of Horne and Ostber'gs MEQ (sMEQ) on chronotype. The sMEQ included 6 items (items 4,7,9,15,17 and 19) from the original MEQ. The answers were scored according to the scoring of the original MEQ. For the single self-evaluation question item 19 was used. The question was used as a binary varable in which those who replied either "rather more an evening than a morning type" or "definitely an evening type" were regarded as evening types, and those who replied "definitely a morning type" or "rather more a morning type than an evening type" were regarrded as morning types. | — | [ ,
47.78 % Male samples |
— | European (Finnish) |
— | FINRISK | Included participants from the National FINRISK 2007 and 2012 studies |
| PSS000452 | Chronotype was assessed using a shortend version of Horne and Ostberg's MEQ(sMEQ) . The sMEQ included 6 items (items 4,7,9,15,17 and 19) from the original MEQ. The answers were scored according to the scoring of the original MEQ. The sum score was used as a binary variable (evening type: socres from 5-15, morning type: socres from 16 to 27; binary sMEQ score). | — | [ ,
46.4 % Male samples |
— | European (Finnish) |
— | FINRISK | Included participants from the National FINRISK 2007 and 2012 studies |
| PSS000453 | Chronotype was assessed using a shortend version of Horne and Ostberg's MEQ(sMEQ) The sMEQ included 6 items (items 4,7,9,15,17 and 19) from the original MEQ. The answers were scored according to the scoring of the original MEQ. The sum score was used as a continuous variable (continuous sMEQ score). | — | 7,436 individuals | — | European (Finnish) |
— | FINRISK | Included participants from the National FINRISK 2007 and 2012 studies |